Quantitative content of carcinoembryonic antigen in endophytic colorectal cancer tumors and colon mucosa
- Authors: Rubtsov V.S.1, Fedotov E.A.1
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Affiliations:
- «Medical Di Center» LLC
- Issue: Vol 36, No 12 (2025)
- Pages: 36-39
- Section: For Diagnosis
- URL: https://journals.rcsi.science/0236-3054/article/view/365673
- DOI: https://doi.org/10.29296/25877305-2025-12
- ID: 365673
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Abstract
Objective. To develop a method for quantitative determination of carcinoembryonic antigen (CEA) content in endophytic cancer tissues and colon mucosa and to assess the possibility of practical application of the obtained data.
Materials and methods. The study material included biopsies of endophytic cancer tumors and mucosa taken during colonoscopy from 16 patients with colorectal cancer and 18 control group patients aged 36 to 72 years. Quantitative determination of CEA content was performed in biopsy homogenates using an modified method using immunochemiluminescent analysis on an automatic analyzer.
Results. The data obtained indicate a significantly higher CEA content in cancer tumor tissues compared to the surrounding mucous membrane and can serve as a basis for laboratory differential diagnostics of colorectal carcinomas with rapid and slow growth rates, including interval cancers.
About the authors
V. S. Rubtsov
«Medical Di Center» LLC
Author for correspondence.
Email: rubzov999@yandex.ru
ORCID iD: 0009-0007-3209-4426
Candidate of Medical Sciences
Russian Federation, EngelsE. A. Fedotov
«Medical Di Center» LLC
Email: rubzov999@yandex.ru
Candidate of Medical Sciences
Russian Federation, EngelsReferences
- Gold F., Freedman S. Demonstration of Tumor-Specific Antigens in Human Colonic Carcinomata by Immunological Tolerance and Absorption Techniques. J Exp Med. 1965; 121 (3): 439–62. doi: 10.1084/jem.121.3.439
- Kankanala V.L., Zubair M., Mukkamalla S.K.R. Carcinoembryonic Antigen. StatPearls. Treasure Island (FL), 2025. URL: https://www.statpearls.com/point-of-care/137650
- Абелев Г.И. Принципы иммунодиагностики опухолей. Иммунология. 1982; 3 (4): 5–12 [Abelev G.I. Printsipy immunodiagnostiki opukholei. Immunologiya. 1982; 3 (4): 5–12 (in Russ.)].
- Hammarström S. The carcinoembryonic antigen (CEA) family: structures, suggested functions and expression in normal and malignant tissues. Semin Cancer Biol. 1999; 9 (2): 67–81. doi: 10.1006/scbi.1998.0119
- Ma Y., Zhang Y., Bi Y. et al. Diagnostic value of carcinoembryonic antigen combined with cytokines in serum of patients with colorectal cancer. Medicine (Baltimore). 2022; 101 (37): e30787. doi: 10.1097/MD.0000000000030787
- Федотова Е.В., Попов В.А. Роль ракового эмбрионального антигена в диагностическом поиске при колоректальной онкопатологии. Современные проблемы науки и образования. 2018; 6: 81 [Fedotova E.V., Popov V.A. The role of cancer embryonic antigen in the diagnostic finding in colorectal tumors. Modern problems of science and education. 2018; 6: 81 (in Russ.)].
- Хасигов А.В., Гагулаева К.В., Батыров К.А. и др. Диагностическая значимость раково-эмбрионального антигена после хирургического удаления опухоли толстой кишки. Всеросс. молодежные исслед. чтения им. акад. А.Д. Сахарова: сб. ст. Всеросс. научно-практ. конф., Петрозаводск, 01 февраля 2021 года. Петрозаводск, 2021; с. 7–11 [Khasigov A.V., Gagulaeva K.V., Batyrov K.A., et al. Diagnostic significance of cancer-embryonic antigen after surgical removal of colon cancer. All-Russian Youth Research Readings named after Academician A.D. Sakharov: collection of articles from the All-Russian Scientific and Practical Conference, Petrozavodsk, February 1, 2021. Petrozavodsk, 2021; pp. 7–11 (in Russ.)].
- Ханкин С.Л., Рубцов В.С., Федотов Э.А. и др. Рак толстой кишки с быстрыми темпами роста. МосЭндо: аккаунт на YouTube. Заседание №210 от 11.09.2024 [Khankin S.L., Rubtsov V.S., Fedotov E.A., et al. Rapidly growing colon cancer. MosEndo: YouTube account. Meeting No. 210 dated September 11, 2024. (in Russ.)]. URL: https://www.youtube.com/watch?v=lGcvQEL518I
- Jansen K., Kornfeld L., Lennartz M. et al. Carcinoembryonic Antigen Expression in Human Tumors: A Tissue Microarray Study on 13,725 Tumors. Cancers (Basel). 2024; 16 (23): 4052. doi: 10.3390/cancers16234052
- Нечай И.А., Суханкина Г.И. Особенности внутрикишечной опухолевой инвазии в проксимальном направлении при раке прямой кишки. Вестник Санкт-Петербургского университета. Серия 11. Медицина. 2007; 1: 80–5 [Nechai LA., Sukhankina G.I. The peculiarities of the intra-intestinal tumor invasion in the proximal direction in patients with the cancer of the rectum. Vestnik Sankt-Peterburgskogo universiteta. Seriya 11. Meditsina. 2007; 1: 80–5 (in Russ.)].
- Эренпрейс Я.Г. Эмбриональные свойства опухолевых клеток: факты и гипотезы. Экспериментальная онкология. 1982; 4 (6): 13–9 [Ehrenpreis YA. G. Ehmbrional'nye svoistva opukholevykh kletok: fakty i gipotezy. Ehksperimental'naya onkologiya. 1982; 4 (6): 13–9 (in Russ.)].
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