Peculiarities of blood cell composition depending on the sequence of manifestation of a number of diseases
- Authors: Saginbaev U.R.1, Rukavishnikova S.A.1, Akhmedov T.A.1, Kovalenko O.Y.2, Nichik E.P.3, Shostak E.E.3,4
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Affiliations:
- Saint Petersburg Institute of Bioregulation and Gerontology
- City Polyclinic of the City of Belgorod
- Research Medical Centre «GERONTOLOGY»
- Clinic of aesthetic medicine DEGA
- Issue: Vol 35, No 8 (2024)
- Pages: 73-76
- Section: From Practice
- URL: https://journals.rcsi.science/0236-3054/article/view/263636
- DOI: https://doi.org/10.29296/25877305-2024-08-15
- ID: 263636
Cite item
Abstract
Aging is a process affecting various organ and tissue systems. The development of age-related changes occurs at the molecular, genetic, cellular, organ and organizational levels. At the population level, accelerated aging can manifest itself as an unfavorable upward dynamics of the incidence of age-associated diseases, an early manifestation of pathology.
Рurpose. To study the features of the cellular composition of the blood depending on the sequence of manifestation of a number of diseases.
Materials and methods. Statistical collections for 2015–2019 acted as materials, clinical blood test (cellular composition of blood) of 17 957 patients hospitalized in Saint-Petersburg City Hospital No 2 from 01.01.2015 to 31.12.2019 with the following diagnoses (ICD-10 codes) is also analyzed: E05, E10, E11, G20, H25, H40, I10, I10–I15, I20, M80–M81, N20–N23.
Results. The analysis established a significant correlation with the priority of disease manifestation for only two indicators: lymphocyte count (r=-0.675; p=0.022) and red blood cells (r=-0.639; p=0.033). Correlation analysis demonstrated a significant association between age-specific incidence index (ASII) and absolute lymphocyte and erythrocyte counts. The sequence of manifestation of the considered diseases, compiled on the basis of ASII ranking, is closely related to the age characteristics of the cellular composition of the blood.
Conclusion. Thus, features of the cellular composition of the blood were found depending on the manifestation of diseases. The identified patterns corresponding to age-related changes will allow the development of new approaches in the study of the pathophysiological gerontological continuum.
Full Text
##article.viewOnOriginalSite##About the authors
U. R. Saginbaev
Saint Petersburg Institute of Bioregulation and Gerontology
Author for correspondence.
Email: ural-spb-sag@mail.ru
ORCID iD: 0000-0001-9709-1882
Candidate of Biological Sciences; Associate Professor
Russian Federation, Saint PetersburgS. A. Rukavishnikova
Saint Petersburg Institute of Bioregulation and Gerontology
Email: ural-spb-sag@mail.ru
ORCID iD: 0000-0002-8161-2425
Biol.D; Associate Professor
Russian Federation, Saint PetersburgT. A. Akhmedov
Saint Petersburg Institute of Bioregulation and Gerontology
Email: ural-spb-sag@mail.ru
ORCID iD: 0000-0002-3105-4322
Biol.D
Russian Federation, Saint PetersburgO. Yu. Kovalenko
City Polyclinic of the City of Belgorod
Email: ural-spb-sag@mail.ru
ORCID iD: 0000-0002-2958-2599
Russian Federation, Belgorod
E. P. Nichik
Research Medical Centre «GERONTOLOGY»
Email: ural-spb-sag@mail.ru
ORCID iD: 0009-0005-2586-4117
Russian Federation, Moscow
E. E. Shostak
Research Medical Centre «GERONTOLOGY»; Clinic of aesthetic medicine DEGA
Email: ural-spb-sag@mail.ru
ORCID iD: 0009-0002-5675-7830
Russian Federation, Moscow; Saint-Petersburg
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