A comparative study of lappaconitine hydrobromide extended release and propafenone in patients with paroxysmal atrial fibrillation
- Authors: Revishvili A.1, Golitsyn S.2, Aksentiev S.3, Amiraslanov A.1, Artyukhina E.1, Duplyakov D.4, Zubov E.5, Isaeva E.6, Loginova A.2, Malkina T.2, Miloserdov G.3, Rivin A.7, Teplykh S.8, Tsygankova I.3, Shvarts Y.9, Yuricheva Y.2, Kanorsky S.10, Sokolov S.2
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Affiliations:
- National Medical Research Center of Surgery named after A.Vishnevsky, Ministry of Health of Russia
- National Medical Research Centre of cardiology named after Academician E.I. Chazov, Ministry of Health of Russia
- Regional Clinical Hospital
- V.P. Polyakov Samara Region Clinical Cardiological Dispensary
- LLC «Professor's Clinic»
- Interregional Clinical Diagnostic Center
- AntMed LLC
- LLC «Center for Professional Medicine»
- Saratov State Medical University named after V.I. Razumovsky
- Kuban State Medical University, Ministry of Health of Russia
- Issue: Vol 35, No 1 (2024)
- Pages: 20-26
- Section: Pharmacology
- URL: https://journals.rcsi.science/0236-3054/article/view/252273
- DOI: https://doi.org/10.29296/25877305-2024-01-04
- ID: 252273
Cite item
Abstract
A new dosage form of lappaconitine hydrobromide has been created – the long-acting drug Allaforte®, which has fewer side effects compared to the traditional dosage form (Allapinin®).
Objective. To evaluate the effectiveness, safety and tolerability of Allaforte® therapy in comparison with the drug Rytmonorm® in patients with paroxysmal atrial fibrillation (AF).
Material and methods. Patients who met the inclusion criteria and those who did not meet the non-inclusion criteria were randomized into 2 groups: 1st (n=50) – patients received Allaforte® 25 mg 3 times a day with an increase in dose to 50 mg 2 times a day when detected attack of AF; 2nd (n=50) – patients received Rytmonorm® 150 mg 3 times a day with an increase in dose to 300 mg 2 times a day if an attack of AF was detected.
Results. The average time from the first dose of the drug to the development of AF paroxysm in the 1st group (Allaforte®) was 98.877±6.022 days, in the 2nd group (Rytmonorm®) – 98.808±5.876 days, the average time from the first dose of the drug to the completion of the study – 105.740±5.032 and 103.732±5.353 days, respectively. The drugs Allaforte® and Rytmonorm® equally improved the quality of life of patients. A comparative analysis in groups according to the severity of adverse events and their cause-and-effect relationship with the drug did not show significant differences.
Conclusion. The study drugs showed comparable effectiveness in preventing attacks of AF with similar safety and tolerability.
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##article.viewOnOriginalSite##About the authors
A. Revishvili
National Medical Research Center of Surgery named after A.Vishnevsky, Ministry of Health of Russia
Author for correspondence.
Email: kanorskysg@mail.ru
Professor, Academician of the Russian Academy of Sciences, MD
Russian Federation, MoscowS. Golitsyn
National Medical Research Centre of cardiology named after Academician E.I. Chazov, Ministry of Health of Russia
Email: kanorskysg@mail.ru
Professor, MD
Russian Federation, MoscowS. Aksentiev
Regional Clinical Hospital
Email: kanorskysg@mail.ru
Candidate of Medical Sciences
Russian Federation, RyazanA. Amiraslanov
National Medical Research Center of Surgery named after A.Vishnevsky, Ministry of Health of Russia
Email: kanorskysg@mail.ru
Russian Federation, Moscow
E. Artyukhina
National Medical Research Center of Surgery named after A.Vishnevsky, Ministry of Health of Russia
Email: kanorskysg@mail.ru
MD
Russian Federation, MoscowD. Duplyakov
V.P. Polyakov Samara Region Clinical Cardiological Dispensary
Email: kanorskysg@mail.ru
Professor, MD
Russian FederationE. Zubov
LLC «Professor's Clinic»
Email: kanorskysg@mail.ru
Candidate of Medical Sciences
Russian Federation, PermE. Isaeva
Interregional Clinical Diagnostic Center
Email: kanorskysg@mail.ru
Candidate of Medical Sciences
Russian Federation, KazanA. Loginova
National Medical Research Centre of cardiology named after Academician E.I. Chazov, Ministry of Health of Russia
Email: kanorskysg@mail.ru
Russian Federation, Moscow
T. Malkina
National Medical Research Centre of cardiology named after Academician E.I. Chazov, Ministry of Health of Russia
Email: kanorskysg@mail.ru
Candidate of Medical Sciences
Russian Federation, MoscowG. Miloserdov
Regional Clinical Hospital
Email: kanorskysg@mail.ru
Russian Federation, Ryazan
A. Rivin
AntMed LLC
Email: kanorskysg@mail.ru
Russian Federation, Saint Petersburg
S. Teplykh
LLC «Center for Professional Medicine»
Email: kanorskysg@mail.ru
Russian Federation, Perm
I. Tsygankova
Regional Clinical Hospital
Email: kanorskysg@mail.ru
Russian Federation, Ryazan
Yu. Shvarts
Saratov State Medical University named after V.I. Razumovsky
Email: kanorskysg@mail.ru
Professor, MD
Russian FederationYu. Yuricheva
National Medical Research Centre of cardiology named after Academician E.I. Chazov, Ministry of Health of Russia
Email: kanorskysg@mail.ru
Candidate of Medical Sciences
Russian Federation, MoscowS. Kanorsky
Kuban State Medical University, Ministry of Health of Russia
Email: kanorskysg@mail.ru
Professor, MD
Russian Federation, KrasnodarS. Sokolov
National Medical Research Centre of cardiology named after Academician E.I. Chazov, Ministry of Health of Russia
Email: kanorskysg@mail.ru
Candidate of Medical Sciences
Russian Federation, MoscowReferences
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