RESTORATION OF FEMALE SEXUAL FUNCTION IN THE REHABILITATION PROGRAM AFTER SURGICAL TREATMENT FOR ENDOMETRIAL CANCER
- Authors: Sandzhieva L.N1, Blinov D.V2,3,4, Solopova A.G1, Achkasov E.E1, Galkin V.N5, Korabelnikov D.I4, Petrenko D.A1
-
Affiliations:
- I.M. Sechenov First Moscow State Medical University (Sechenov University), Ministry of Health of Russia
- Institute of Preventive and Social Medicine
- Lapino Clinical Hospital, Village of Lapino
- F.P. Gaaz Moscow Sociomedical Institute
- City Clinical Oncology Hospital One, Moscow Healthcare Department
- Issue: Vol 33, No 10 (2022)
- Pages: 60-66
- Section: Articles
- URL: https://journals.rcsi.science/0236-3054/article/view/142962
- DOI: https://doi.org/10.29296/25877305-2022-10-12
- ID: 142962
Cite item
Abstract
Objective. To evaluate the effectiveness of the developed comprehensive personalized rehabilitation program in restoring sexual function in female patients after radical treatment for endometrial cancer (EC). Subjects and methods. The investigation involved 61 reproductive-aged patients with histologically verified endometrioid carcinoma after radical surgery. The women were randomized into 2 groups: 1) 29 patients treated with an active rehabilitation through a comprehensive restorative program; 2) 32 patients treated with a passive rehabilitation, whose management corresponded to clinical recommendations. Follow-ups were performed at 1 week and 3, 6, and 12 months after surgery. Each visit included clinical examination and assessment of sexual function, by using the FSFI questionnaire. Results. Statistically significant differences between the groups were obtained after 6 and 12 months. At the end of the study, the total FSFI score showed an almost complete recovery of sexual function in the active rehabilitation group (a total FSFI score of 24.93±2.86), unlike the comparison group (a total FSFI score of 13.39±2.55; p < 0.001). Conclusion. Comprehensive personalized rehabilitation mitigates the consequences of radical surgery in patients with EC, contributing to the restoration of sexual function within 1 year after surgery.
Full Text
##article.viewOnOriginalSite##About the authors
L. N Sandzhieva
I.M. Sechenov First Moscow State Medical University (Sechenov University), Ministry of Health of Russia
Email: antoninasolopova@yandex.ru
Russian Federation
D. V Blinov
Institute of Preventive and Social Medicine; Lapino Clinical Hospital, Village of Lapino; F.P. Gaaz Moscow Sociomedical Institute
Email: antoninasolopova@yandex.ru
Candidate of Medical Sciences
Russian FederationA. G Solopova
I.M. Sechenov First Moscow State Medical University (Sechenov University), Ministry of Health of Russia
Email: antoninasolopova@yandex.ru
доктор медицинских наук, профессор
Russian FederationE. E Achkasov
I.M. Sechenov First Moscow State Medical University (Sechenov University), Ministry of Health of Russia
Email: antoninasolopova@yandex.ru
Professor, MD
Russian FederationV. N Galkin
City Clinical Oncology Hospital One, Moscow Healthcare Department
Email: antoninasolopova@yandex.ru
Professor, MD
Russian FederationD. I Korabelnikov
F.P. Gaaz Moscow Sociomedical Institute
Email: antoninasolopova@yandex.ru
Professor, MD
Russian FederationD. A Petrenko
I.M. Sechenov First Moscow State Medical University (Sechenov University), Ministry of Health of Russia
Author for correspondence.
Email: antoninasolopova@yandex.ru
Russian Federation
References
- Sung H. et al. Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 2021; 71 (3): 209-49. doi: 10.3322/caac.21660
- Fernandez-Montoli M.E., Sabadell J., Contreras-Perez N.A. Fertility-Sparing Treatment for Atypical Endometrial Hyperplasia and Endometrial Cancer: A Cochrane Systematic Review Protocol. Adv Ther. 2021; 38 (5): 2717-31. doi: 10.1007/s12325-021-01693-y
- Каприн А.Д., Старинский В.В., Шахзадова А.О. Злокачественные новообразования в России в 2020 году (заболеваемость и смертность). М.: МНИОИ им. П.А. Герцена -филиал ФГБУ «НМИЦ радиологии» Минздрава России, 2021; c. 252.
- Солопова А.Г., Блинов Д.В., Бегович Е., и др. Неврологические расстройства после гистерэктомии: от патогенеза к клинике. Эпилепсия и пароксизмальные состояния. 2022; 14 (1): 54-64. doi: 10.17749/2077-8333/epi.par.con.2022.115
- Власина А.Ю., Идрисова Л.Э., Солопова А.Г. и др. Реабилитация онкогинекологических больных после противоопухолевой терапии: пути решения. Акушерство, Гинекология и Репродукция. 2020; 14 (1): 44-55. doi: 10.17749/2313-7347.2020.14.1.44-55
- Son J., Carr C., Yao M. et al. Endometrial cancer in young women: prognostic factors and treatment outcomes in women aged №40 years.Int J Gynecol Cancer. 2020; 30 (5): 631-9. doi: 10.1136/ijgc-2019-001105
- Natavio K.M.A., Billod J.A. Sexual dysfunction among patients with endometrial cancer at a tertiary training public institution: A cross-sectional study. Philippine J Obstet Gynecol. 2021; 45 (6): 608-12. doi: 10.1097/IGC.0000000000000905
- Karatajli V., Can B., Qakir I. et al. Life quality of endometrioid endometrial cancer survivors: a cross-sectional study. J Obstet Gynaecol. 2021; 41 (4): 621-5. doi: 10.1080/01443615.2020.1787969
- Rizzuto I., Oehler M.K., Lalondrelle S. Sexual and Psychosexual Consequences of Treatment for Gynaecological Cancers. Clin Oncol. 2021; 33 (9): 602-7. DOI: 10.1016/j. clon.2021.07.003
- Smith S.R., Zheng J.Y., Silver J. et al. Cancer rehabilitation as an essential component of quality care and survivorship from an international perspective. Disabil Rehabil. 2018; 42 (1): 8-13. doi: 10.1080/09638288.2018.1514662
- Рак тела матки и саркомы матки. Клинические рекомендации. Минздрав России. 2020. Электронный ресурс. URL: https://cr.minzdrav.gov.ru/recomend/460_3
- Власина А.Ю., Солопова А.Г., Сон Е.А. и др. Психоэмоциональное благополучие и сексуальная функция больных пограничными опухолями яичников. Акушерство, Гинекология и Репродукция. 2020; 14 (5): 551-67. doi: 10.17749/2313-7347/ob.gyn. rep.2020.147
- Wiegel M., Meston C., Rosen R. The female sexual function index (FSFI): crossvalidation and development of clinical cutoff scores. J Sex Marital Ther. 2005; 31 (1): 1-20. doi: 10.1080/00926230590475206
- Smith T., Kingsberg S.A., Faubion S. Sexual dysfunction in female cancer survivors: Addressing the problems and the remedies. Maturitas. 2022; 165: 52-7. DOI: 10.1016/j. maturitas.2022.07.010
- Hosseini S.E., Ilkhani M., Rohani C. et al. Prevalence of sexual dysfunction in women with cancer: A systematic review and meta-analysis.Int J Reprod BioMed. 2022; 20: 1-12. doi: 10.18502/ijrm.v20i1.10
- Gao J., Tian J., Lv Y. et al. Leptin induces functional activation of cyclooxygenase-2 through JAK2/STAT3, MAPK/ERK, and PI3K/AKT pathways in human endometrial cancer cells. Cancer Sci. 2009; 100 (3): 389-95. doi: 10.1111/j.1349-7006.2008.01053.x
- Onujiogu N., Johnson, T., Seo. et al. Survivors of endometrial cancer: who is at risk for sexual dysfunction? Gynecol Oncol. 2011; 123 (2): 356-9. doi: 10.1016/j.ygyno.2011.07.035
- Блинов Д.В., Солопова А.Г, Плутницкий А.Н. и др. Организация здравоохранения в сфере реабилитации больных с онкологическими заболеваниями репродуктивной системы. ФАРМАКОЭКОНОМИКА. Современная фармакоэкономика и фармакоэпидемиология. 2022; 15 (1): 119-30. doi: 10.17749/2070-4909/ farmakoekonomika.2022.132
- Солопова А.Г., Блинов Д.В., Демьянов С.В. и др. Эпигенетические аспекты в реабилитации онкологических больных женщин. ФАРМАКОЭКОНОМИКА. Современная фармакоэкономика и фармакоэпидемиология. 2022; 15 (2): 294-303. doi: 10.17749/2070-4909/farmakoekonomika.2022.141