Synthesis, Structure, and Properties of the Iron Nitrosyl Complex with 2-Ethyl-4-pyridinecarbothioamide

N. A. Sanina; Санина Н. А.; G. V. Shilov; Шилов Г. В.; N. S. Ovanesyan; Ованесян Н. С.; V. A. Mumyatova; Мумятова В. А.; A. A. Balakina; Балакина А. А.; A. A. Terent’ev; Терентьев А. А.; O. V. Pokidova; Покидова О. В.; S. M. Aldoshin; Алдошин С. М.

doi:10.31857/S0132344X23600169

Synthesis, Structure, and Properties of the Iron Nitrosyl Complex with 2-Ethyl-4-pyridinecarbothioamide

Authors: Sanina N.A.¹^,2^,3, Shilov G.V.¹, Ovanesyan N.S.¹, Mumyatova V.A.¹, Balakina A.A.¹, Terent’ev A.A.¹^,2^,3, Pokidova O.V.¹, Aldoshin S.M.¹
Affiliations:
1. Federal Research Center of Problems of Chemical Physics and Medicinal Chemistry, Russian Academy of Sciences, Chernogolovka, Russia
2. Research and Education Center “Medicinal Chemistry” in Chernogolovka, State University of Education, Mytishchi, Moscow oblast, Russia
3. Moscow State University, Moscow, Russia
Issue: Vol 49, No 9 (2023)
Pages: 530-542
Section: Articles
URL: https://journals.rcsi.science/0132-344X/article/view/137307
DOI: https://doi.org/10.31857/S0132344X23600169
EDN: https://elibrary.ru/WBRISE
ID: 137307

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Abstract
About the authors
References
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Abstract

The synthesis and data on the physicochemical characteristics and biological activity of the new
iron nitrosyl complex (Q+)2[Fe2(S2O3)2(NO)4]2– (I), where Q+ is protonated 2-ethyl-4-pyridinecarbothioamide
(C8H11N2S), are presented. The structure and properties of the complex were studied by X-ray diffraction,
elemental analysis, IR and Mössbauer spectroscopy, and amperometry. The complex showed antibacterial
activity and efficiently inhibited cyclic guanosine monophosphate phosphodiesterase (cGMP PDE),
which may suggest its antihypertensive, anti-aggregation, and vasodilator activities.

Keywords

binuclear iron(I) tetranitrosyl complexes, X-ray diffraction, IR spectroscopy, Mössbauer spectroscopy, amperometry, antibacterial activity, biofilms, ampicillin, kanamycin, streptomycin, ceftriaxone, MTT assay, phosphodiesterase

About the authors

N. A. Sanina

Federal Research Center of Problems of Chemical Physics and Medicinal Chemistry, Russian Academy of Sciences,
Chernogolovka, Russia; Research and Education Center “Medicinal Chemistry” in Chernogolovka, State University of Education,
Mytishchi, Moscow oblast, Russia; Moscow State University, Moscow, Russia

Email: sanina@icp.ac.ru
Россия, Черноголовка; Россия, Мытищи; Россия, Москва

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