The Structure of Sulfated Polysaccharides from the Sea Cucumber  Holothuria  ( Stauropora )  fuscocinerea

M. I. Bilan; Билан М. И.; A. I. Usov; Усов А. И.; Tran Thi Thanh Van; Van Tran Thi Thanh; Dinh Thanh Trung; Trung Dinh Thanh; Pham Duc Thinh; Thinh Pham Duc; Cao Thi Thuy Hang; Hang Cao Thi Thuy; N. E. Ustyuzhanina; Устюжанина Н. Е.; E. A. Tsvetkova; Цветкова Е. А.; S. P. Nikogosova; Никогосова С. П.; A. S. Dmitrenok; Дмитренок А. С.; N. E. Nifantiev; Нифантьев Н. Э.

doi:10.31857/S0132342323040309

The Structure of Sulfated Polysaccharides from the Sea Cucumber Holothuria (Stauropora) fuscocinerea

作者: Bilan M.¹, Usov A.¹, Van T.², Trung D.², Thinh P.², Hang C.², Ustyuzhanina N.¹, Tsvetkova E.¹, Nikogosova S.¹, Dmitrenok A.¹, Nifantiev N.¹
隶属关系:
1. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences
2. NhaTrang Institute of Technology Research and Application, Vietnam Academy of Science and Technology
期: 卷 49, 编号 4 (2023)
页面: 392-402
栏目: Articles
URL: https://journals.rcsi.science/0132-3423/article/view/139173
DOI: https://doi.org/10.31857/S0132342323040309
EDN: https://elibrary.ru/ODDRCN
ID: 139173

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详细

Fucosylated chondroitin sulfate FCS-Hf and preparations of fucan sulfates Hf-Fuc1 and Hf-Fuc2 were isolated from the Vietnamese sea cucumber Holothuria (Stauropora) fuscocinerea. Separation of the polysaccharides was carried out using anion-exchange chromatography on DEAE-Sephacel. The structure of polysaccharides was established by determinations of the content of monosaccharides and sulfate, as well as by NMR spectra. It was shown that FCS-Hf was built of the repeating trisaccharide fragments, with alternating 3‑linked N-acetyl-β-D-galactosamine and 4-linked β-D-glucuronic acid residues forming the main polymer chain, which carries α-L-fucose residues as side branches attached to O3 of glucuronic acid. The regular structure of polymer is masked by an uneven distribution of sulfate groups attached to fucose residues (2,4-disulfate, 3,4-disulfate and 4-monosulfate in a ratio of 2 : 2 : 1) and galactosamine residues (4,6-disulfate and 4-monosulfate in a ratio of 3 : 1). It was also shown that fucan sulfate Hf-Fuc1 contained predominantly linear molecules built of 4-linked α-L-fucose 3-sulfate residues, while Hf-Fuc2 appeared to be a mixture of several related linear and branched fucan sulfates containing 3-linked and 4-linked α-L-Fuc residues sulfated at different positions.

关键词

Holothuria (Stauropora) fuscocinerea, sea cucumber, polysaccharides, fucosylated chondroitin sulfate, fucan sulfate

参考

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