Gender Differences in Microcirculatory Bed Parameters According to High-Frequency Doppler Ultrasonography

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Abstract

The study is aimed at analyzing the differences in central hemodynamics and blood flow in the microcirculatory bed in men and women to identify specific gender characteristics of microcirculation. The study involved 84 women and 406 men. Three-fold measurement of arterial pressure on the brachial artery was performed using the MediTechMT-25 Palm device (USA). Blood flow parameters were measured at rest using high-frequency ultrasound dopplergraphy on the skin of the nail fold of the index finger of the right hand. The subjects were in a sitting position, the hand on which the measurement was performed was on a solid support at the level of the heart. The dopplergraph «Minimax-Doppler-K» (Russia) with a 20 MHz sensor was used for the study. Analysis of the results revealed statistically significant differences in microcirculation parameters between men and women. Women had higher values of blood flow velocity in the arteriolar (Vm: 0.98 cm/s vs. 0.91 cm/s, p = 0.040; Vs: 1.55 cm/s vs. 1.38 cm/s, p < 0.001; Vas: 0.81 cm/s vs. 0.55 cm/s, p = 0.003) and venular links (Vad: 0.34 cm/s vs. 0.25 cm/s, p = 0.002). In men, this is compensated by higher values of capillary blood flow (Vam: 0.16 cm/s vs. 0.19 cm/s, p = 0.030), as well as volumetric blood flow in the capillaries (Qam: 0.08 ml/min vs. 0.11 ml/min, p < 0.001). In addition, women have higher pulsatility indices (PI: 1.35 vs. 1.16, p = 0.014) and circulatory tension indices (RI: 0.80 vs. 0.73, p = 0.026).

About the authors

M. A Skedina

Institute of Biomedical Problems of the Russian Academy of Sciences

Email: skedina07@rambler.ru
ORCID iD: 0000-0003-4369-966X
Ph.D. in Medicine, Leading Researcher Moscow, Russian Federation

A. A Kovaleva

Institute of Biomedical Problems of the Russian Academy of Sciences

Email: hitraja_niusha@mail.ru
ORCID iD: 0000-0002-3697-1007
Researcher Moscow, Russian Federation

N. A Konstantinova

Institute of Biomedical Problems of the Russian Academy of Sciences

Email: nataly_kon@mail.ru
ORCID iD: 0000-0001-6587-1470
Ph.D. in Biology, Leading researcher Moscow, Russian Federation

A. A Artamonov

Institute of Biomedical Problems of the Russian Academy of Sciences

Email: anton.art.an@gmail.com
ORCID iD: 0000-0002-7543-9611
Ph.D. in Biology, Senior researcher Moscow, Russian Federation

References

  1. Huxley V.H., Kemp S.S. Sex-specific characteristics of the microcirculation // Adv. Exp. Med. Biol. 2018. V. 1065. P. 307.
  2. Panazzolo D.G., da Silva L.H.A., de Almeida Cyrino F.Z.G. et al. Gender differences in microcirculation: Observation using the hamster cheek pouch // Clinics. 2013. V. 68. № 12. P. 1537.
  3. Huxley V.H. Sex and the cardiovascular system: the intriguing tale of how women and men regulate cardiovascular function differently // Adv. Physiol. Educ. 2007. V. 31. № 1. P. 17.
  4. Shim C.Y., Park S., Choi D. et al. Sex differences in central hemodynamics and their relationship to left ventricular diastolic function // J. Am. Coll. Cardiol. 2011. V. 57. № 10. P. 1226.
  5. Muiesan M.L., Salvetti M., Rizzoni D. et al. Pulsatile hemodynamics and microcirculation: Evidence for a close relationship in hypertensive patients // Hypertension. 2013. V. 61. № 1. P. 130.
  6. Munoz C.J., Lucas A., Williams A.T., Cabrales P.A. Review on microvascular hemodynamics // Crit. Care Clin. 2020. V. 36. № 2. P. 293.
  7. Guven G., Hilty M.P., Ince C. Microcirculation: Physiology, pathophysiology, and clinical application // Blood Purif. 2020. V. 49. № 1–2. P. 143.
  8. Hayward C.S., Kelly R.P. Gender-related differences in the central arterial pressure waveform // J. Am. Coll. Cardiol. 1997. V. 30. № 7. P. 1863.
  9. Higashi H., Okayama H., Saito M. et al. Relationship between augmentation index and left ventricular diastolic function in healthy women and men // Am. J. Hypertens. 2013. V. 26. № 11. P. 1280.
  10. Svensson C., Eriksson P., Bjarnegård N. et al. Impaired microcirculation and vascular hemodynamics in relation to macrocirculation in patients with systemic lupus erythematosus // Front. Med. (Lausanne). 2021. V. 8. P. 722758.
  11. Федорович А.А., Горшков А.Ю., Королев А.Н. и др. Гендерные различия структурно-функционального состояния микроциркуляторного русла кожи у лиц с впервые выявленной артериальной гипертензией // Кардиоваскулярная терапия и профилактика. 2023. Т. 22. № 8. С. 15.
  12. Омельяненко К.В., Горшков А.Ю., Федорович А.А. и др. Гендерные особенности микроциркуляторного русла кожи у здоровых лиц трудоспособного возраста // Кардиоваскулярная терапия и профилактика. 2021. Т. 20. № 8. С. 48.
  13. Sullivan S., Young A., Garcia M. et al. Sex differences in microvascular response to mental stress and adverse cardiovascular events among patients with ischemic heart disease // Arterioscler. Thromb. Vasc. Biol. 2023. V. 43. № 4. P. e112.
  14. Глазков А.А., Глазкова П.А., Куликов Д.А., Роганкин Д.А. Влияние гендерных различий на параметры микротехнологических, оцененные в ходе тепловой и окклюзионной проб // Регионарное кровообращение и микроциркуляция. 2022. Т. 21. № 4. С. 33.
  15. Jonasson H., Bergstrand S., Fredriksson I. et al. Normative data and the influence of age and sex on microcirculatory function in a middle-aged cohort: Results from the SCAPIS study // Am. J. Physiol. Heart Circ. Physiol. 2020. V. 318. № 4. P. H908.
  16. Stupin A., Stupin M., Baric L. et al. Sex-related differences in forearm skin microvascular reactivity of young healthy subjects // Clin. Hemorheol. Microcirc. 2019. V. 72. № 4. P. 339.
  17. Бабошина Н.В. Показатели микроциркуляции у лиц обоего пола в разном возрасте // Физиология человека. 2018. Т. 44. № 4. С. 107.
  18. Подзолков В.И., Васильева Л.В., Матвеев В.В., Колесниченко Н.А. Половые особенности микроциркуляции у здоровых лиц и пациентов с артериальной гипертензией первой степени // Рациональная фармакотерапия в кардиологии. 2012. Т. 8. № 6. С. 451.
  19. Grau M., Cremer J.M., Schmeichel S. et al. Comparisons of blood parameters, red blood cell deformability and circulating nitric oxide between males and females considering hormonal contraception: A longitudinal gender study // Front. Physiol. 2018. V. 9. P. 1835.

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