Email this article 
Determination of immunological indicators in predicting the severity of cardiovascular diseases
- Authors: Krylov A.S.1, Myagkova M.A.2, Petrochenko S.N.3
-
Affiliations:
- Dianark LLC
- Federal Research Center for Problems of Chemical Physics and Medical Chemistry RAS
- Institute of Biomedical Problems, RAS
- Issue: Vol 51, No 1 (2025)
- Pages: 76-83
- Section: Articles
- URL: https://journals.rcsi.science/0131-1646/article/view/286001
- DOI: https://doi.org/10.31857/S0131164625010079
- EDN: https://elibrary.ru/VMSIJC
- ID: 286001
Cite item
Open Access
Access granted
Abstract
The development of new tools in the system for predicting the development of cardiovascular diseases (CVD) is an urgent task. The determination of immunoindicators – natural antibodies (e-Ab) to serotonin, dopamine, angiotensin, histamine, characterizing the course of CVD, was studied to assess the severity of the disease using a mathematical balance model based on visualization of laboratory analysis results. The determination of e-Abs was carried out in groups of patients differing in diagnosis (1-hypertension (45 people), 2-hypertension and coronary heart disease (53 people), 3-control (41 people)). It was found that, compared to the control, there was an increase in the level of e-Abs to bioregulators from 44 to 76% and from 46 to 119% (p < 0.05) for patients of the 1st and 2nd groups, respectively. As the severity of CVD progresses, the number of individuals with significantly high ELISA values for angiotensin and serotonin increases. The use of a mathematical balance model to predict the course of CVD showed that the value of the platform deviation angle is a summary indicator reflecting the metabolic disorder of each bioregulator. The results obtained are confirmed by the medical report for each patient.
Full Text
About the authors
A. S. Krylov
Dianark LLC
Email: dianark777@mail.ru
Russian Federation, Moscow
M. A. Myagkova
Federal Research Center for Problems of Chemical Physics and Medical Chemistry RAS
Email: dianark777@mail.ru
Institute of Physiologically Active Substances
Russian Federation, Chernogolovka, Moscow regionS. N. Petrochenko
Institute of Biomedical Problems, RAS
Author for correspondence.
Email: dianark777@mail.ru
Institute of Physiologically Active Substances
Russian Federation, Chernogolovka, Moscow regionReferences
- Saigitov R.T., Chulok A.A. [Cardiovascular diseases in the context of socio-economic priorities of long-term development of Russia] // Bull. Russ. Acad. Med. Sci. 2015. № 70(3). P. 286.
- Orlov O.I., Perevedentsev O.V., Mamonova E.Y., Levanov V.M. [Method of automated complex analysis of health status and medical support in extreme conditions of industrial activity] // Aviakosm. Ekolog. Med. 2017. V. 51. № 4. P. 39.
- Shlyakhto E.V., Zvartau N.E., Villevalde S.V. et al. [Cardiovascular risk management system: prerequisites for creation, principles of organization, target groups] // Russ. J. Cardiol. 2019. № 24(11). P. 69.
- Knyazev E.G., Samchenko A.A., Ryumkin K.V. [Тhe formation of a system to support medical decision-making based on the digitization of clinical guidelines using formal logic tools] // Qual. Management Med. 2019. № 4. P. 52.
- Lebedev G.S., Fartushny E.N., Shaderkin I.A. et al. [Bilding of the medical decision support system on the basis of providing medicine based on evidence-based medicine] // Russ. J. Telemed. eHealth. 2019. V. 5. № 1. P. 8.
- Sakulin S.A. Аggregation operators visualization using 3d cognitive graphics // Bull. Comput. Inf. Technol. 2022. V. 19. № 3(213). P. 15.
- Myagkova M.A., Orlova E.A., Petrochenko S.N., Bobrova Z.V., Bachurin S.O. [Analysis of immunobiochemical parameters in overweight people in assessing the risk of cardiovascular diseases] // Bull. Exp. Biol. Med. 2022. V. 174. № 10. P. 452.
- Morozova V.S., Moseikin I.A., Petrochenko S.N., Myagkova M.A., Panchenko L.F. [Analysis of immune–biochemical indicators to assess the risk of developing cardiological pathology] // Dokl. Biochem. Biophys. 2017. V. 437. № 2. P. 225.
- Nikulina N.N., Yakushin S.S. [The modern aspects of diagnosis formulation and statistical recording of myocardial infarction] // Kardiologiia. 2016. V. 56. № 9. P. 60.
- Myagkova M.A., Petrochenko S.N., Morozova V.S. Detection of natural antibodies to endogenous bioregulators for the diagnostics of the functional state of the body // Russ. Chem. Bull. 2018. V. 67. № 4. P. 762.
- Zuo1 L-J., Yu Sh.-Y., Hu Y. et al. Serotonergic dysfunctions and abnormal iron metabolism: relevant to mental fatigue of Parkinson disease // Sci. Rep. 2016. V. 6. № 1. P. 19.
- Igonkina S.I., Vetrile L.A., Kukushkin M.L. [The effect of antibodies to norepinephrine on the development of neuropathic pain] // Bull. Exp. Biol. Med. 2016. V. 162. № 12. P. 678.
- Nieto-Alamilla G., Márquez-Gómez R., García-Gálvez A.-M. et al. The histamine H3 receptor: Structure, pharmacology, and function // Mol. Pharmacol. 2016. V. 90. P. 649.
- Gordeev A.V., Galushko E.A., Savushkina N.M. [The role of angiotensins in the pathogenesis of inflammatory joint diseases] // Ter. Arkh. 2021. V. 93. № 5. P. 635.
- Pongpanich P., Pitakpaiboonkul P., Takkavatakarn K. et al. The benefits of angiotensin-converting enzyme inhibitors/angiotensin II receptor blockers combined with calcium channel blockers on metabolic, renal, and cardiovascular outcomesin hypertensive patients: a meta-analysis // Int. Urol. Nephrol. 2018. V. 50. № 12. P. 226.
Supplementary files
