Slow negative potentials in the pre-stimulus period in norm and patients with the first episode of schizophrenia

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Abstract

Behavioral data (correct response latency and errors number increase) indicate a significant decrease in the task performance efficiency in patients with the first episode of schizophrenia, compared to the norm. At the same time the SNP 1, 2, 3 amplitudes were found to enhance in the patients group, compared to the norm, which may reflect a compensatory activation of predictive attention and inhibition cortical networks for increase the response efficiency. Intergroup differences in the topography of the SNP1 and SNP2 peaks amplitude suggest “disorganization” of the left hemisphere cognitive control cortical networks at the early stage of schizophrenia. It is assumed that the SNP 1, 2, 3 components can be considered as potentially significant clinically markers of cognitive control disorders in schizophrenia.

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About the authors

M. V. Slavutskaya

Moscow State University; Center for Mental Health

Author for correspondence.
Email: mvslav@yandex.ru
Russian Federation, Moscow; Moscow

I. S. Lebedeva

Center for Mental Health

Email: mvslav@yandex.ru
Russian Federation, Moscow

A. А. Fedotova

Moscow State University

Email: mvslav@yandex.ru
Russian Federation, Moscow

D. V. Tikhonov

Center for Mental Health

Email: mvslav@yandex.ru
Russian Federation, Moscow

V. G. Kaleda

Center for Mental Health

Email: mvslav@yandex.ru
Russian Federation, Moscow

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Supplementary files

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2. Fig. 1. Experimental scheme of "Go/NoGo delay". CFS — central fixation stimulus, SS — signal stimulus, TS — target stimuli ("Go" or "NoGo").

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3. Fig. 2. Slow averaged potentials of the electroencephalogram (EEG) in the pre-stimulus period (–1056 ms) of a left saccade (A) and fragments of EEG mapping of their amplitude in the group of healthy subjects and in the group of patients with the first episode of schizophrenia (B). A — EEG averaging in healthy subjects (solid line, n = 279) and patients (dotted line, n = 281). The arrow indicates the inclusion of target stimuli (TS) (averaging trigger, 0 ms). B — fragment of EEG mapping of the amplitude of slow potentials in the pre-stimulus interval in the normal group (1) and in the patient group (2). The mapping step is 32 ms. 1 – red foci in the interval from –992 to 800 ms – MNP1 component, from –608 to –384 – MNP2 component, from –224 to 0 ms – MNP3 component. 2 – red foci in the interval from –960 to –608 ms – MNP1 component, from –448 to –288 – MNP2 component, from –128 to 0 – MNP3 component.

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