Analysis of Ectonucleotide Pyrophosphatase/Phosphodiesterase 1 Gene K121Q Polymorphism Association with Some Risk Factors of Atherosclerosis in Patients with Acute Coronary Syndrome
- Авторы: Ataman A.1, Harbuzova V.1, Obukhova O.1, Dubovyk Y.1
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Учреждения:
- Sumy State University
- Выпуск: Том 52, № 2 (2018)
- Страницы: 127-131
- Раздел: Article
- URL: https://journals.rcsi.science/0095-4527/article/view/173856
- DOI: https://doi.org/10.3103/S0095452718020020
- ID: 173856
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Аннотация
The present study was performed to investigate whether common single-nucleotide polymorphism K121Q (rs1044498) of the ENPP1 gene is associated with the known risk factors of atherosclerosis (overweight, dyslipoproteinemia, hypertension, diabetes, smoking, and hypercoagulability) in persons with acute coronary syndrome. Venous blood of 118 patients was genotyped for the polymorphism by PCR and restriction fragment length polymorphism method. In patients divided into two subgroups according to their genotype (KK and KQ + QQ), the statistically significant differences were revealed only for plasma LDL-cholesterol level and fibrinolytic activity. The carriers of minor allele (KQ + QQ) had lower LDL-cholesterol concentration and the time of fibrinolysis than the major allele homozygotes (KK). The division of patients into subgroups according to presence or absence of some risk factors for atherosclerosis showed no statistically significant differences between K121Q genotype distributions for any of the comparison.
Об авторах
A. Ataman
Sumy State University
Email: v.garbuzova@med.sumdu.edu.ua
Украина, Sumy, 40007
V. Harbuzova
Sumy State University
Автор, ответственный за переписку.
Email: v.garbuzova@med.sumdu.edu.ua
Украина, Sumy, 40007
O. Obukhova
Sumy State University
Email: v.garbuzova@med.sumdu.edu.ua
Украина, Sumy, 40007
Ye. Dubovyk
Sumy State University
Email: v.garbuzova@med.sumdu.edu.ua
Украина, Sumy, 40007