Expression of Tlr2, Defa, and Muc2 genes in rat duodenum epithelial cells during prolonged stomach hypoacidity and after hypoacidity correction by multiprobiotics
- Авторы: Dranitsina A.1, Dvorshchenko K.1, Morgaienko O.1, Grebinyk D.1, Ostapchenko L.1
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Учреждения:
- Institute of Biology
- Выпуск: Том 50, № 3 (2016)
- Страницы: 196-202
- Раздел: Article
- URL: https://journals.rcsi.science/0095-4527/article/view/173409
- DOI: https://doi.org/10.3103/S009545271603004X
- ID: 173409
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Аннотация
Expression of Tlr2, Defa, and Muc2 genes in epithelial cells of rat duodenum during prolonged stomach hypoacidity (hypochlorhydria) and after hypoacidity correction by multiprobiotics has been investigated. Elevation of Tlr2, Muc2, and Defa gene expression levels upon the intensification of lipid peroxidation processes in the epithelial cells of the villi and crypts of the rat duodenum under hypoacidic conditions has been demonstrated. Administration of a multiprobiotic under the same conditions downregulated the expression of the aforementioned genes in epithelial cells of the villi and crypts, bringing it to a nearly normal level, and exerted a similar effect on the levels of lipid peroxidation products. The data obtained may be indicative of the involvement of Tlr2, Muc2, and Defa genes in the development of duodenal inflammation induced by dysbiotic changes occurring in prolonged hypochlorhydria.
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Об авторах
A. Dranitsina
Institute of Biology
Автор, ответственный за переписку.
Email: alevtina.dranitsina@gmail.com
Украина, Kyiv
K. Dvorshchenko
Institute of Biology
Email: alevtina.dranitsina@gmail.com
Украина, Kyiv
O. Morgaienko
Institute of Biology
Email: alevtina.dranitsina@gmail.com
Украина, Kyiv
D. Grebinyk
Institute of Biology
Email: alevtina.dranitsina@gmail.com
Украина, Kyiv
L. Ostapchenko
Institute of Biology
Email: alevtina.dranitsina@gmail.com
Украина, Kyiv