Influence of Filipendula ulmaria (L.) Maxim. Extract on Lewis Lung Carcinoma Development and Cytostatic Therapy Effectiveness in Mice


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Meadowsweet extract was prepared by heating the aerial part of Filipendula ulmaria (L.) Maxim. in EtOH (70%). Experiments in C57BL/6 mice with Lewis lung carcinoma (LLC) showed that the extract at doses of 50 and 100 mg/kg exhibited dose-dependent antimetastatic action. Combined treatment of animals with LLC using cyclophosphamide and meadowsweet extract at doses of 50 and 100 mg/kg increased the antitumor effect of the cytostatic drug.

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E. Amosova

E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk National Research Medical Center, Russian Academy of Sciences

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Email: nii@pharmso.ru
俄罗斯联邦, 3 Prosp. Lenina, Tomsk, 634028

I. Shilova

E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk National Research Medical Center, Russian Academy of Sciences

Email: nii@pharmso.ru
俄罗斯联邦, 3 Prosp. Lenina, Tomsk, 634028

E. Zueva

E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk National Research Medical Center, Russian Academy of Sciences

Email: nii@pharmso.ru
俄罗斯联邦, 3 Prosp. Lenina, Tomsk, 634028

O. Rybalkina

E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk National Research Medical Center, Russian Academy of Sciences

Email: nii@pharmso.ru
俄罗斯联邦, 3 Prosp. Lenina, Tomsk, 634028

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