Biological Surveying of Diverse Schiff Base Compounds: Antiproliferative, Antiradical and Enzyme Inhibition Activity
- 作者: Paşa S.1, Tuneğ M.2, Boğa M.2
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隶属关系:
- Department of Science, Faculty of Education, Afyon Kocatepe University
- Department of Pharmaceutical Technology, Faculty of Pharmacy, Dicle University
- 期: 卷 53, 编号 4 (2019)
- 页面: 302-311
- 栏目: Article
- URL: https://journals.rcsi.science/0091-150X/article/view/245744
- DOI: https://doi.org/10.1007/s11094-019-01997-y
- ID: 245744
如何引用文章
详细
Schiff base compounds (((1Z,1′Z)-(((ethane-1,2-diylbis(sulfanediyl))bis(2,1-phenylene))bis(azanylylidene)) bis(methanylylidene)) bis(4,1-phenylene))diboronic acid (1), 1,1′-((1Z,1′Z)-([1,1′-biphenyl]-4,4′-diylbis( azanylylidene)) bis(methanylylidene)) bis(naphthalen-2-ol) (2), 4,4′-((1Z,1′Z)-([1,1′-biphenyl]-4,4′-diylbis(azanylylidene)) bis(methanylylidene)) bis(2-methoxy phenol) (3), (N4Z,N4′Z)-N4,N4′-bis(4-(dimethyl amino) benzylidene)-[1,1′-biphenyl]-4,4′-diamine (4), (E)-2-((2-hydroxybenzylidene)amino) terephthalic acid (5), and (E)-2-(((2-hydroxynaphthalen-1-yl)methylene)amino)terephthalic acid (6) have been synthesized. The structural identification was confirmed by spectroscopic techniques. The antiproliferative, antiradical, and enzyme activities were investigated in biological experimen0ts. The obtained results showed that Schiff base compounds 1 – 6 exhibited meaningful features in various biological tests. A comparison of compound 1 (containing boron atom in the structure) to compounds 2 – 6 shows that the inclusion of boron in the Schiff base determines whether this would increase or not the efficiency in biological experiments. Hereby, compound 1 exhibited significantly different results in all applications.
作者简介
Salih Paşa
Department of Science, Faculty of Education, Afyon Kocatepe University
编辑信件的主要联系方式.
Email: drsalihpasa@gmail.com
土耳其, Afyonkarahisar, 03200
Muhammed Tuneğ
Department of Pharmaceutical Technology, Faculty of Pharmacy, Dicle University
Email: drsalihpasa@gmail.com
土耳其, Diyarbakir, 21280
Mehmet Boğa
Department of Pharmaceutical Technology, Faculty of Pharmacy, Dicle University
Email: drsalihpasa@gmail.com
土耳其, Diyarbakir, 21280