Synthesis, Characterization and Biological Evaluations of New Imidazo[4,5-a]Acridines as Potential Antibacterial Agents
- 作者: Karimi N.1, Pordel M.1, Davoodnia A.1, Sadeghian H.2, Mousavian M.3
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隶属关系:
- Department of Chemistry, Mashhad Branch, Islamic Azad University
- Department of Laboratory Sciences, Mashhad University of Medical Sciences
- Department of Chemistry, Payame Noor University of Mashhad
- 期: 卷 53, 编号 1 (2019)
- 页面: 52-56
- 栏目: Article
- URL: https://journals.rcsi.science/0091-150X/article/view/245605
- DOI: https://doi.org/10.1007/s11094-019-01955-8
- ID: 245605
如何引用文章
详细
The significance of bacterial infections and the early success achieved with some antibiotic drugs have prompted the search for new antibacterial agents. Some new derivatives of 3H-imidazo[4,5-a]acridines are introduced as new powerful antibacterial agents against Gram-positive species. The reaction of N-alkyl-5-nitrobenzimidazoles with arylacetonitriles under basic conditions led to the synthesis of 3H-imidazo[4′,5′:3,4]benzo[c]isoxazoles. Rearrangement of the latter compounds in concentrated sulfuric acid containing nitrous acid gave imidazo[4,5-a]acridones. 3H-imidazo[4,5-a]acridines were obtained by reaction of imidazo[4,5-a]acridones in boiling POCl3. Finally, new compounds were synthesized from the reaction of 3H-imidazo[4,5-a]acridine derivatives with aromatic amines in high yields. All new compounds were fully characterized by elemental analysis, IR, NMR and mass spectroscopy data. Antibacterial activity of the new compounds was tested against a panel of strains of Gram-negative and Gram-positive bacteria species and the corresponding minimum bactericidal concentration (MBC) values were determined. Results of the antimicrobial screening tests showed that new compounds are very effective against Gram-positive bacteria and their MBC values are comparable with those of well-known antibacterial agents such as cephalexin.
作者简介
Nasrin Karimi
Department of Chemistry, Mashhad Branch, Islamic Azad University
Email: Mehdipordel58@mshdiau.ac.ir
伊朗伊斯兰共和国, Mashhad
Mehdi Pordel
Department of Chemistry, Mashhad Branch, Islamic Azad University
编辑信件的主要联系方式.
Email: Mehdipordel58@mshdiau.ac.ir
伊朗伊斯兰共和国, Mashhad
Abolghasem Davoodnia
Department of Chemistry, Mashhad Branch, Islamic Azad University
Email: Mehdipordel58@mshdiau.ac.ir
伊朗伊斯兰共和国, Mashhad
Hamid Sadeghian
Department of Laboratory Sciences, Mashhad University of Medical Sciences
Email: Mehdipordel58@mshdiau.ac.ir
伊朗伊斯兰共和国, Mashhad
Mina Mousavian
Department of Chemistry, Payame Noor University of Mashhad
Email: Mehdipordel58@mshdiau.ac.ir
伊朗伊斯兰共和国, Mashhad