Synthesis and Antitumor and Antibacterial Activity of Novel Dihydronaphthaline and Dihydrobenzo[H]Quinazoline Derivatives
- 作者: Markosyan A.1, Airapetyan K.1, Gabrielyan S.1, Mamyan S.1, Shirinyan V.2, Zakharov A.2, Arsenyan F.1, Avakimyan D.1, Stepanyan G.1
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隶属关系:
- A. L. Mndzhoyan Institute of Fine Organic Chemistry, Scientific-Technological Center for Organic and Pharmaceutical Chemistry, National Academy of Sciences of the Republic of Armenia
- N. D. Zelinskii Institute of Organic Chemistry, Russian Academy of Sciences
- 期: 卷 53, 编号 1 (2019)
- 页面: 15-22
- 栏目: Article
- URL: https://journals.rcsi.science/0091-150X/article/view/245592
- DOI: https://doi.org/10.1007/s11094-019-01948-7
- ID: 245592
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详细
A method for the synthesis of 1-amino-3,3-dimethyl-3,4-dihydronaphthaline-2-carbonitrile (β-aminonitrile) was developed and used to synthesize Schiff bases, thioureide and chloracetamide derivatives. This latter was cyclized to 5,5-dimethyl-2-chloromethyl-5,6-dihydrobenzo[h]quinazoline-4(3H)-one, which was used to synthesize a series of 2-sulfanylmethyl and 2-aminomethyl derivatives. 2-Chloromethylbenzo[h]quinazoline in the presence of a base was found to form condensed heterocyclic compounds with seven rings: 1,1,11,11-tetramethyl-1,2,11,12-tetrahydropyrazino[2,1-b:5,4-b′]di(benzo[h]quinazoline)-10,16(8H,18H)-di one. The antitumor properties of the compounds synthesized here were studied in an ascites carcinoma model and the antibacterial properties were studied using the agar diffusion method.
作者简介
A. Markosyan
A. L. Mndzhoyan Institute of Fine Organic Chemistry, Scientific-Technological Center for Organic and Pharmaceutical Chemistry, National Academy of Sciences of the Republic of Armenia
编辑信件的主要联系方式.
Email: ashot@markosyan.am
亚美尼亚, 26 Azatutyan Prospekt, Erevan, 0014
K. Airapetyan
A. L. Mndzhoyan Institute of Fine Organic Chemistry, Scientific-Technological Center for Organic and Pharmaceutical Chemistry, National Academy of Sciences of the Republic of Armenia
Email: ashot@markosyan.am
亚美尼亚, 26 Azatutyan Prospekt, Erevan, 0014
S. Gabrielyan
A. L. Mndzhoyan Institute of Fine Organic Chemistry, Scientific-Technological Center for Organic and Pharmaceutical Chemistry, National Academy of Sciences of the Republic of Armenia
Email: ashot@markosyan.am
亚美尼亚, 26 Azatutyan Prospekt, Erevan, 0014
S. Mamyan
A. L. Mndzhoyan Institute of Fine Organic Chemistry, Scientific-Technological Center for Organic and Pharmaceutical Chemistry, National Academy of Sciences of the Republic of Armenia
Email: ashot@markosyan.am
亚美尼亚, 26 Azatutyan Prospekt, Erevan, 0014
V. Shirinyan
N. D. Zelinskii Institute of Organic Chemistry, Russian Academy of Sciences
Email: ashot@markosyan.am
俄罗斯联邦, 47 Lenin Prospekt, Moscow, 119991
A. Zakharov
N. D. Zelinskii Institute of Organic Chemistry, Russian Academy of Sciences
Email: ashot@markosyan.am
俄罗斯联邦, 47 Lenin Prospekt, Moscow, 119991
F. Arsenyan
A. L. Mndzhoyan Institute of Fine Organic Chemistry, Scientific-Technological Center for Organic and Pharmaceutical Chemistry, National Academy of Sciences of the Republic of Armenia
Email: ashot@markosyan.am
亚美尼亚, 26 Azatutyan Prospekt, Erevan, 0014
Dzh. Avakimyan
A. L. Mndzhoyan Institute of Fine Organic Chemistry, Scientific-Technological Center for Organic and Pharmaceutical Chemistry, National Academy of Sciences of the Republic of Armenia
Email: ashot@markosyan.am
亚美尼亚, 26 Azatutyan Prospekt, Erevan, 0014
G. Stepanyan
A. L. Mndzhoyan Institute of Fine Organic Chemistry, Scientific-Technological Center for Organic and Pharmaceutical Chemistry, National Academy of Sciences of the Republic of Armenia
Email: ashot@markosyan.am
亚美尼亚, 26 Azatutyan Prospekt, Erevan, 0014