Antidepressant Effect of a Dipeptide Brain-Derived-Neurotrophic-Factor Mimetic (GSB-106) in a Generic Oral Dosage Form
- 作者: Tallerova A.1, Povarnina P.1, Blynskaya E.1, Bueva V.1, Alekseev K.1, Gudasheva T.1, Seredenin S.1
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隶属关系:
- Zakusov State Institute of Pharmacology, Russian Academy of Medical Sciences
- 期: 卷 52, 编号 5 (2018)
- 页面: 397-399
- 栏目: Article
- URL: https://journals.rcsi.science/0091-150X/article/view/245207
- DOI: https://doi.org/10.1007/s11094-018-1828-z
- ID: 245207
如何引用文章
详细
A deficiency of brain-derived neurotrophic factor (BDNF) has now been demonstrated in many studies to play a central role in the pathogenesis of depression. The dimeric dipeptide BDNF-mimetic bis(N-monosuccinyl-L-seryl-L-lysine) hexamethylenediamide or GSB-106 was discovered at Zakusov State Institute of Pharmacology. Previously, the antidepressant properties of GSB-106 at doses of 0.1 – 1 mg/kg i.p. were established in mice in the Porsolt forced swim test. An oral dosage form of GSB-106 was developed. The present research focused on the antidepressant activity of the GSB-106 dosage form in mice in the Porsolt forced swim test. It is established that GSB-106 in the oral dosage form possesses antidepressant activity for 14 d at doses of 0.05, 0.1, and 1 mg/kg.
作者简介
A. Tallerova
Zakusov State Institute of Pharmacology, Russian Academy of Medical Sciences
Email: gudasheva@academpharm.ru
俄罗斯联邦, Moscow, 125315
P. Povarnina
Zakusov State Institute of Pharmacology, Russian Academy of Medical Sciences
Email: gudasheva@academpharm.ru
俄罗斯联邦, Moscow, 125315
E. Blynskaya
Zakusov State Institute of Pharmacology, Russian Academy of Medical Sciences
Email: gudasheva@academpharm.ru
俄罗斯联邦, Moscow, 125315
V. Bueva
Zakusov State Institute of Pharmacology, Russian Academy of Medical Sciences
Email: gudasheva@academpharm.ru
俄罗斯联邦, Moscow, 125315
K. Alekseev
Zakusov State Institute of Pharmacology, Russian Academy of Medical Sciences
Email: gudasheva@academpharm.ru
俄罗斯联邦, Moscow, 125315
T. Gudasheva
Zakusov State Institute of Pharmacology, Russian Academy of Medical Sciences
编辑信件的主要联系方式.
Email: gudasheva@academpharm.ru
俄罗斯联邦, Moscow, 125315
S. Seredenin
Zakusov State Institute of Pharmacology, Russian Academy of Medical Sciences
Email: gudasheva@academpharm.ru
俄罗斯联邦, Moscow, 125315