Antioxidant Properties of Herbal Mixtures Improving Cognitive-Mnestic Functions
- 作者: Shilova I.1,2, Suslov N.1,2, Korotkova E.3, Samylina I.4, Petrova E.3, Mazin E.1, Kovaleva T.4, Minakova M.1
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隶属关系:
- E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk National Medical Research Center, Russian Academy of Sciences
- National Research Tomsk State University
- National Research Tomsk Polytechnic University
- Sechenov First Moscow State Medical University
- 期: 卷 51, 编号 8 (2017)
- 页面: 678-682
- 栏目: Medicinal Plants
- URL: https://journals.rcsi.science/0091-150X/article/view/244753
- DOI: https://doi.org/10.1007/s11094-017-1673-5
- ID: 244753
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详细
Decoctions of herbal mixtures I (including 30% Filipendula ulmaria meadowsweet grass, 10% bilberry shoots, and 60% Bergenia crassifolia green leaves) and II (60% meadowsweet grass, 10% bilberry shoots, and 30% bergenia green leaves) exhibited antioxidant activity. Biologically active substances of herbal mixture I exhibited predominantly catalytic decomposition of hydrogen peroxide formed during electroreduction of oxygen. Active substances of herbal mixture II interacted with oxygen radicals generated as a result of oxygen electroreduction on the electrode surface (EC mechanism) and were more effective than both dihydroquercetin and ascorbic acid. Herbal mixtures I and II normalized the content of thiobarbiturate-reactive products in brain homogenates under conditions of hypoxia-activated lipid peroxidation. In addition, herbal mixture II reduced the concentration of antiradical antioxidants in the lipid extracts. The antioxidant properties were inherent to a greater extent in mixture II dominated by meadowsweet grass, which contained the most complete sum of biologically active phenolic substances (simple phenols, flavonoids, hydroxycoumarins, phenolcarboxylic acids, mainly hydrolyzable tannins), amino acids, and macro- and microelements.
作者简介
I. Shilova
E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk National Medical Research Center, Russian Academy of Sciences; National Research Tomsk State University
编辑信件的主要联系方式.
Email: nii@pharmso.ru
俄罗斯联邦, 3 Prosp. Lenina, Tomsk, 634028; 36 Prosp. Lenina, Tomsk, 634050
N. Suslov
E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk National Medical Research Center, Russian Academy of Sciences; National Research Tomsk State University
Email: nii@pharmso.ru
俄罗斯联邦, 3 Prosp. Lenina, Tomsk, 634028; 36 Prosp. Lenina, Tomsk, 634050
E. Korotkova
National Research Tomsk Polytechnic University
Email: nii@pharmso.ru
俄罗斯联邦, 30 Prosp. Lenina, Tomsk, 634050
I. Samylina
Sechenov First Moscow State Medical University
Email: nii@pharmso.ru
俄罗斯联邦, 8/2 Trubetskaya St., Moscow, 119991
E. Petrova
National Research Tomsk Polytechnic University
Email: nii@pharmso.ru
俄罗斯联邦, 30 Prosp. Lenina, Tomsk, 634050
E. Mazin
E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk National Medical Research Center, Russian Academy of Sciences
Email: nii@pharmso.ru
俄罗斯联邦, 3 Prosp. Lenina, Tomsk, 634028
T. Kovaleva
Sechenov First Moscow State Medical University
Email: nii@pharmso.ru
俄罗斯联邦, 8/2 Trubetskaya St., Moscow, 119991
M. Minakova
E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk National Medical Research Center, Russian Academy of Sciences
Email: nii@pharmso.ru
俄罗斯联邦, 3 Prosp. Lenina, Tomsk, 634028