Synthesis and Anthelmintic and Insecticidal Activities of 1-R-3-Methyl-6-Methoxy-7-(  P -Propoxy)-3,4-Dihydroisoquinoline Hydrochlorides

O. V. Surikova; A. G. Mikhailovskii; B. Ya. Syropyatov; A. S. Yusov

doi:10.1007/s11094-017-1533-3

Synthesis and Anthelmintic and Insecticidal Activities of 1-R-3-Methyl-6-Methoxy-7-( P-Propoxy)-3,4-Dihydroisoquinoline Hydrochlorides

作者: Surikova O.V.¹, Mikhailovskii A.G.¹, Syropyatov B.Y.¹, Yusov A.S.¹
隶属关系:
1. Perm State Pharmaceutical Academy
期: 卷 50, 编号 12 (2017)
页面: 794-797
栏目: Article
URL: https://journals.rcsi.science/0091-150X/article/view/244480
DOI: https://doi.org/10.1007/s11094-017-1533-3
ID: 244480

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1-R-3-Methyl-6-methoxy-7-(n-propoxy)-3,4-dihydroisoquinolines were synthesized via cyclocondensation of O-n-propyleugenol with various nitriles. It was shown that the hydrochlorides of the synthesized compounds exhibited anthelmintic and weak insecticidal activity. The isoquinoline containing a 1-benzyl radical had the greatest anthelmintic activity and was more potent than pyrantel and imidacloprid.