Synthesis and Antiproliferative Activity of New Acylcatechins
- 作者: Pozdeev A.1, Rasadkina E.1, Burym A.1, Knyazev V.2, Koroteev M.1, Matyushin A.2, Koroteev A.1, Semeikin A.2, Shimanovskii N.2
-
隶属关系:
- Institute of Biology and Chemistry, Department of Organic Chemistry, Moscow State Pedagogical University
- Medical-Biology Department, Pirogov Russian National Research Medical University
- 期: 卷 50, 编号 8 (2016)
- 页面: 523-525
- 栏目: Article
- URL: https://journals.rcsi.science/0091-150X/article/view/244428
- DOI: https://doi.org/10.1007/s11094-016-1481-3
- ID: 244428
如何引用文章
详细
New peracyl derivatives of the natural flavonoid (±)-catechin were synthesized. It was shown that carboxylic-acid acyl residues enhanced to various degrees the cytotoxicity of peracyl catechins against HeLa cell line. The structures of the synthesized compounds were confirmed by PMR and 13C NMR spectroscopy and elemental analysis. The catechins were compared with previously studied analogous dihydroquercetin derivatives.
关键词
作者简介
A. Pozdeev
Institute of Biology and Chemistry, Department of Organic Chemistry, Moscow State Pedagogical University
编辑信件的主要联系方式.
Email: Chemdept@mail.ru
俄罗斯联邦, 3 Nesvizhskii Per., Moscow, 119021
E. Rasadkina
Institute of Biology and Chemistry, Department of Organic Chemistry, Moscow State Pedagogical University
Email: Chemdept@mail.ru
俄罗斯联邦, 3 Nesvizhskii Per., Moscow, 119021
A. Burym
Institute of Biology and Chemistry, Department of Organic Chemistry, Moscow State Pedagogical University
Email: Chemdept@mail.ru
俄罗斯联邦, 3 Nesvizhskii Per., Moscow, 119021
V. Knyazev
Medical-Biology Department, Pirogov Russian National Research Medical University
Email: Chemdept@mail.ru
俄罗斯联邦, 9A/1 Bol’shaya Pirogovskaya St., Moscow, 119435
M. Koroteev
Institute of Biology and Chemistry, Department of Organic Chemistry, Moscow State Pedagogical University
Email: Chemdept@mail.ru
俄罗斯联邦, 3 Nesvizhskii Per., Moscow, 119021
A. Matyushin
Medical-Biology Department, Pirogov Russian National Research Medical University
Email: Chemdept@mail.ru
俄罗斯联邦, 9A/1 Bol’shaya Pirogovskaya St., Moscow, 119435
A. Koroteev
Institute of Biology and Chemistry, Department of Organic Chemistry, Moscow State Pedagogical University
Email: Chemdept@mail.ru
俄罗斯联邦, 3 Nesvizhskii Per., Moscow, 119021
A. Semeikin
Medical-Biology Department, Pirogov Russian National Research Medical University
Email: Chemdept@mail.ru
俄罗斯联邦, 9A/1 Bol’shaya Pirogovskaya St., Moscow, 119435
N. Shimanovskii
Medical-Biology Department, Pirogov Russian National Research Medical University
Email: Chemdept@mail.ru
俄罗斯联邦, 9A/1 Bol’shaya Pirogovskaya St., Moscow, 119435