Synthesis and Antiproliferative Activity of New Acylcatechins


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New peracyl derivatives of the natural flavonoid (±)-catechin were synthesized. It was shown that carboxylic-acid acyl residues enhanced to various degrees the cytotoxicity of peracyl catechins against HeLa cell line. The structures of the synthesized compounds were confirmed by PMR and 13C NMR spectroscopy and elemental analysis. The catechins were compared with previously studied analogous dihydroquercetin derivatives.

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A. Pozdeev

Institute of Biology and Chemistry, Department of Organic Chemistry, Moscow State Pedagogical University

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俄罗斯联邦, 3 Nesvizhskii Per., Moscow, 119021

E. Rasadkina

Institute of Biology and Chemistry, Department of Organic Chemistry, Moscow State Pedagogical University

Email: Chemdept@mail.ru
俄罗斯联邦, 3 Nesvizhskii Per., Moscow, 119021

A. Burym

Institute of Biology and Chemistry, Department of Organic Chemistry, Moscow State Pedagogical University

Email: Chemdept@mail.ru
俄罗斯联邦, 3 Nesvizhskii Per., Moscow, 119021

V. Knyazev

Medical-Biology Department, Pirogov Russian National Research Medical University

Email: Chemdept@mail.ru
俄罗斯联邦, 9A/1 Bol’shaya Pirogovskaya St., Moscow, 119435

M. Koroteev

Institute of Biology and Chemistry, Department of Organic Chemistry, Moscow State Pedagogical University

Email: Chemdept@mail.ru
俄罗斯联邦, 3 Nesvizhskii Per., Moscow, 119021

A. Matyushin

Medical-Biology Department, Pirogov Russian National Research Medical University

Email: Chemdept@mail.ru
俄罗斯联邦, 9A/1 Bol’shaya Pirogovskaya St., Moscow, 119435

A. Koroteev

Institute of Biology and Chemistry, Department of Organic Chemistry, Moscow State Pedagogical University

Email: Chemdept@mail.ru
俄罗斯联邦, 3 Nesvizhskii Per., Moscow, 119021

A. Semeikin

Medical-Biology Department, Pirogov Russian National Research Medical University

Email: Chemdept@mail.ru
俄罗斯联邦, 9A/1 Bol’shaya Pirogovskaya St., Moscow, 119435

N. Shimanovskii

Medical-Biology Department, Pirogov Russian National Research Medical University

Email: Chemdept@mail.ru
俄罗斯联邦, 9A/1 Bol’shaya Pirogovskaya St., Moscow, 119435


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