Improved Voriconazole Topical Delivery by Nanoparticles (Minireview)
- 作者: Nassiri-Kashani M.1, Namdar R.2,3, Nafisi S.2,3, Maibach H.3
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隶属关系:
- Center for Research and Training in Skin Diseases and Leprosy, Tehran University of Medical Sciences
- Department of Chemistry, Central Tehran Branch
- Department of Dermatology, University of California
- 期: 卷 50, 编号 2 (2016)
- 页面: 76-79
- 栏目: Article
- URL: https://journals.rcsi.science/0091-150X/article/view/244322
- DOI: https://doi.org/10.1007/s11094-016-1401-6
- ID: 244322
如何引用文章
详细
Voriconazole is a triazole antifungal drug used to treat invasive fungal infections including candidiasis, aspergillosis, and certain emerging fungal infections. Voriconazole demonstrates low water solubility. Therefore, drug solubilization is necessary for effective topical delivery. Nano-strategy may overcome its poor aqueous solubility as well as controlled drug release at action site, reduction of total dose, avoidance of systemic absorption and dosage form retention on skin. In topical antifungal administration, drug should pass outermost layer of skin; stratum corneum to reach lower layers, particularly into follicular epithelium. Nano-formulations including colloidal systems, vesicular carriers, and nanoparticles may play a major role for enhancing antifungals permeation profile. Present review surveys key experiments with voriconazole nano-based formulations used in superficial fungal infections treatment.
作者简介
Mansour Nassiri-Kashani
Center for Research and Training in Skin Diseases and Leprosy, Tehran University of Medical Sciences
Email: maibachh@derm.ucsf.edu
伊朗伊斯兰共和国, Tehran
Roshanak Namdar
Department of Chemistry, Central Tehran Branch; Department of Dermatology, University of California
Email: maibachh@derm.ucsf.edu
伊朗伊斯兰共和国, Tehran, IAU; San Francisco, CA
Shohreh Nafisi
Department of Chemistry, Central Tehran Branch; Department of Dermatology, University of California
编辑信件的主要联系方式.
Email: drshnafisi@gmail.com
伊朗伊斯兰共和国, Tehran, IAU; San Francisco, CA
Howard Maibach
Department of Dermatology, University of California
编辑信件的主要联系方式.
Email: maibachh@derm.ucsf.edu
美国, San Francisco, CA