Отправить статью по E-mail Synthesis and Anti-Inflammatory Activity of Tyrosol and Its Structural Analogs
- Авторы: Krysin A.P.1, Tolstikova T.G.1, Dolgikh M.P.1, Shul’ts E.E.1, Pokrovskii L.M.1
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Учреждения:
- N. N. Vorozhtsov Novosibirsk Institute of Organic Chemistry, Siberian Branch, Russian Academy of Sciences
- Выпуск: Том 52, № 11 (2019)
- Страницы: 907-911
- Раздел: Article
- URL: https://journals.rcsi.science/0091-150X/article/view/245531
- DOI: https://doi.org/10.1007/s11094-019-01924-1
- ID: 245531
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Аннотация
The anti-inflammatory activity of tyrosol and 12 structural analogs including 3 new compounds was determined. Several structure-activity (anti-inflammatory) relationships were found. Adding a tert-butyl substituent to the aromatic ring and increasing the length of the alkyl chain decreased the anti-inflammatory activity. Pronounced antiulcer activity was found for p-tyrosol.
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A. Krysin
N. N. Vorozhtsov Novosibirsk Institute of Organic Chemistry, Siberian Branch, Russian Academy of Sciences
Email: schultz@nioch.ru
Россия, 9 Prosp. Akad. Lavrent’eva, Novosibirsk, 630090
T. Tolstikova
N. N. Vorozhtsov Novosibirsk Institute of Organic Chemistry, Siberian Branch, Russian Academy of Sciences
Email: schultz@nioch.ru
Россия, 9 Prosp. Akad. Lavrent’eva, Novosibirsk, 630090
M. Dolgikh
N. N. Vorozhtsov Novosibirsk Institute of Organic Chemistry, Siberian Branch, Russian Academy of Sciences
Email: schultz@nioch.ru
Россия, 9 Prosp. Akad. Lavrent’eva, Novosibirsk, 630090
E. Shul’ts
N. N. Vorozhtsov Novosibirsk Institute of Organic Chemistry, Siberian Branch, Russian Academy of Sciences
Автор, ответственный за переписку.
Email: schultz@nioch.ru
Россия, 9 Prosp. Akad. Lavrent’eva, Novosibirsk, 630090
L. Pokrovskii
N. N. Vorozhtsov Novosibirsk Institute of Organic Chemistry, Siberian Branch, Russian Academy of Sciences
Email: schultz@nioch.ru
Россия, 9 Prosp. Akad. Lavrent’eva, Novosibirsk, 630090
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