Synthesis and Anti-Inflammatory Activity of Tyrosol and Its Structural Analogs

A. P. Krysin; T. G. Tolstikova; M. P. Dolgikh; E. E. Shul’ts; L. M. Pokrovskii

doi:10.1007/s11094-019-01924-1

Synthesis and Anti-Inflammatory Activity of Tyrosol and Its Structural Analogs

Авторы: Krysin A.¹, Tolstikova T.¹, Dolgikh M.¹, Shul’ts E.¹, Pokrovskii L.¹
Учреждения:
1. N. N. Vorozhtsov Novosibirsk Institute of Organic Chemistry, Siberian Branch, Russian Academy of Sciences
Выпуск: Том 52, № 11 (2019)
Страницы: 907-911
Раздел: Article
URL: https://journals.rcsi.science/0091-150X/article/view/245531
DOI: https://doi.org/10.1007/s11094-019-01924-1
ID: 245531

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Аннотация

The anti-inflammatory activity of tyrosol and 12 structural analogs including 3 new compounds was determined. Several structure-activity (anti-inflammatory) relationships were found. Adding a tert-butyl substituent to the aromatic ring and increasing the length of the alkyl chain decreased the anti-inflammatory activity. Pronounced antiulcer activity was found for p-tyrosol.