Comparison of the Antitumor Efficacy of Bismuth and Gadolinium as Dose-Enhancing Agents in Formulations for Photon Capture Therapy
- Autores: Lipengol’ts A.1,2,3, Cherepanov A.1, Kulakov V.2, Grigor’eva E.1, Merkulova I.1, Sheino I.2
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Afiliações:
- N. N. Blokhin Russian Oncological Scientific Center
- A. I. Burnazyan Federal Medical Biophysics Center
- National Nuclear Research University MIFI
- Edição: Volume 51, Nº 9 (2017)
- Páginas: 783-786
- Seção: Article
- URL: https://journals.rcsi.science/0091-150X/article/view/244801
- DOI: https://doi.org/10.1007/s11094-017-1693-1
- ID: 244801
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Resumo
The efficacy of photon capture therapy (PCT) is to a significant extent determined by the properties of the formulation containing the element efficiently absorbing external X-irradiation and operating as a dose-enhancing agent (DEA). We report here a comparison of the efficacies of bismuth and gadolinium as DEA in PCT technologies with X-irradiation at 110 kV for the treatment of superficial tumors. Bismuth and gadolinium are comparable in that they are available as the same chemical form – a complex with diethylenetriaminepentaacetic acid, for which the physicochemical properties are similar for both elements. Studies were performed on mice with transplanted B16F10 melanoma as a tumor model. Both DEAwere given by the intratumor route at the same dose of 5 mg of DEAper animal. Irradiation was with an x-ray apparatus with a tension of 110 kV using a dose of 20 Gy. The results showed significantly greater antitumor efficacy for PCT with both gadolinium and bismuth than with short-focus radiotherapy. In terms of the log dead cells (lgN), there was an increase in lgN from 0.78 for short-focus irradiation to 2.5 for PCT using gadolinium or bismuth, with identical dose exposure. There were no significant differences in the antitumor efficacies of PCT with bismuth and gadolinium for x-ray irradiation at 110 kV.
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Sobre autores
A. Lipengol’ts
N. N. Blokhin Russian Oncological Scientific Center; A. I. Burnazyan Federal Medical Biophysics Center; National Nuclear Research University MIFI
Email: chem@folium.ru
Rússia, 24 Kashirskoe Chaussee, Moscow; 46 Zhivopisnaya Street, Moscow; 31 Kashirskoe Chausee, Moscow
A. Cherepanov
N. N. Blokhin Russian Oncological Scientific Center
Email: chem@folium.ru
Rússia, 24 Kashirskoe Chaussee, Moscow
V. Kulakov
A. I. Burnazyan Federal Medical Biophysics Center
Email: chem@folium.ru
Rússia, 46 Zhivopisnaya Street, Moscow
E. Grigor’eva
N. N. Blokhin Russian Oncological Scientific Center
Email: chem@folium.ru
Rússia, 24 Kashirskoe Chaussee, Moscow
I. Merkulova
N. N. Blokhin Russian Oncological Scientific Center
Email: chem@folium.ru
Rússia, 24 Kashirskoe Chaussee, Moscow
I. Sheino
A. I. Burnazyan Federal Medical Biophysics Center
Email: chem@folium.ru
Rússia, 46 Zhivopisnaya Street, Moscow