Synthesis, Characterization and Antimicrobial Activity of Two Novel Sulfonamide Schiff Base Compounds
- Autores: Tahriri M.1, Yousefi M.1, Mehrani K.1, Tabatabaee M.2, Ashkezari M.3
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Afiliações:
- Department of Chemistry Science and Research Branch, Islamic Azad University
- Department of Chemistry, Yazd Branch, Islamic Azad University
- Department of Biology, Ashkezar Branch, Islamic Azad University
- Edição: Volume 51, Nº 5 (2017)
- Páginas: 425-428
- Seção: Article
- URL: https://journals.rcsi.science/0091-150X/article/view/244637
- DOI: https://doi.org/10.1007/s11094-017-1626-z
- ID: 244637
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Resumo
Reactions of 2-hydroxy-3-methoxybenzaldehyde with p-toluenesulfonyl hydrazide and 4-nitrosulfonyl hydrazide under classical heating led to the corresponding sulfonamide Schiff bases 1 and 2. Both synthesized compounds were characterized by their spectroscopic data and elemental analysis. The antimicrobial activity of 1 and 2 against Gram-positive bacteria Staphylococcus epidermidis and Staphylococcus saprophyticus and Gram-negative bacteria Proteus mirabilis has been investigated by disc diffusion and minimum inhibitory concentration (MIC) methods. The disc diffusion method was also used to study antifungal activity of compounds against Aspergillus fumigates, Aspergillus clavatus, and Aspergillus flavus. Vancomycin and sulfamethoxazole/trimethoprim were used as standard drugs for bacteria and miconazole was used as antifungal standard.
Sobre autores
Mozhgan Tahriri
Department of Chemistry Science and Research Branch, Islamic Azad University
Email: tabatabaee@iauyazd.ac.ir
Irã, Tehran
Mohammad Yousefi
Department of Chemistry Science and Research Branch, Islamic Azad University
Email: tabatabaee@iauyazd.ac.ir
Irã, Tehran
Kheirollah Mehrani
Department of Chemistry Science and Research Branch, Islamic Azad University
Email: tabatabaee@iauyazd.ac.ir
Irã, Tehran
Masoumeh Tabatabaee
Department of Chemistry, Yazd Branch, Islamic Azad University
Autor responsável pela correspondência
Email: tabatabaee@iauyazd.ac.ir
Irã, Yazd
Mahmood Ashkezari
Department of Biology, Ashkezar Branch, Islamic Azad University
Email: tabatabaee@iauyazd.ac.ir
Irã, Yazd