Synthesis of New 6-[4-(2-Fluorophenylpiperazine-1-YL)]-3(2H)-Pyridazinone-2-Acethyl-2- (Substitutedbenzal)Hydrazone Derivatives and Evulation of Their Cytotoxic Effects in Liver and Colon Cancer Cell Lines
- Авторлар: Özdemir Z.1, Başak-Türkmen N.2, Ayhan İ.3, Çiftçi O.4, Uysal M.5
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Мекемелер:
- Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Inonu University
- Department of Pharmaceutical Toxicology, Faculty of Pharmacy, Inonu University
- Department of Medical Pharmacology, Faculty of Medicine, Yıldırım Beyazıt University
- Department of Medical Pharmacology, Faculty of Medicine, Pamukkale University
- Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Gazi University
- Шығарылым: Том 52, № 11 (2019)
- Беттер: 923-929
- Бөлім: Article
- URL: https://journals.rcsi.science/0091-150X/article/view/245539
- DOI: https://doi.org/10.1007/s11094-019-01927-y
- ID: 245539
Дәйексөз келтіру
Аннотация
In this study, seven new 3(2H)-pyridazinone derivatives expected to show cytotoxic activity in liver and colon cancer cell lines were synthesized. Their structures were confirmed by the IR, 1H-NMR, 13C-NMR spectra and elementary analyses. Compunds V1-V7 were tested on HEP3B (liver cancer) and HTC116 (colon cancer) cell lines for cytotoxicity by using MTS [3-(4,5-dimethylthiazol-2-yl)-5-(3-carboxymethoxyphenyl)-2-(4-sulfophenyl)- 2H-tetrazolium] proliferation assay. Human fibroblast cells were used as safety control in these tests. 6-[4-(2-Fluorophenyl)piperazine-1-yl]-3(2H)-pyridazinone-2-acetyl-2-(2-chlorobenzal)hydrazone (compound V3 ) was the most active agent with respect to HEP3B and HTC116 cell lines.
Негізгі сөздер
Авторлар туралы
Zeynep Özdemir
Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Inonu University
Хат алмасуға жауапты Автор.
Email: zeynep.bulut@inonu.edu.tr
Түркия, Malatya, 44280
Neşe Başak-Türkmen
Department of Pharmaceutical Toxicology, Faculty of Pharmacy, Inonu University
Email: zeynep.bulut@inonu.edu.tr
Түркия, Malatya, 44280
İdris Ayhan
Department of Medical Pharmacology, Faculty of Medicine, Yıldırım Beyazıt University
Email: zeynep.bulut@inonu.edu.tr
Түркия, Ankara, 06100
Osman Çiftçi
Department of Medical Pharmacology, Faculty of Medicine, Pamukkale University
Email: zeynep.bulut@inonu.edu.tr
Түркия, Denizli, 20160
Mehtap Uysal
Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Gazi University
Email: zeynep.bulut@inonu.edu.tr
Түркия, Ankara, 06100