Biochemical Evaluation of Copper Compounds Derived from O- and N-/O- Donor Ligands
- Авторлар: Akhtar M.1, Shahid M.2, Sadakiyo M.3, Ikram M.4, Rehman S.4, Ahmed I.5
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Мекемелер:
- Department of Chemistry, University of Agriculture
- Department of Biochemistry, University of Agriculture
- International Institute for Carbon-Neutral Energy Research (I2CNER), Kyushu University
- Department of Chemistry, Abdul Wali Khan University
- Department of Pharmacy, The Islamia University of Bahawalpur
- Шығарылым: Том 51, № 4 (2017)
- Беттер: 272-276
- Бөлім: Article
- URL: https://journals.rcsi.science/0091-150X/article/view/244565
- DOI: https://doi.org/10.1007/s11094-017-1596-1
- ID: 244565
Дәйексөз келтіру
Аннотация
Compounds [CuII2(benz)4(Hbenz)2] (1) and [CuII(ppa)2(H2O)2]n (2), where benz = benzoate and ppa = 3-pyridinepropionic acid, were synthesized and studied for their 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging activity and the inhibition of enzymes such as acetylcholinesterase (AChE), butyrylcholinesterase (BChE), lipoxygenase (LOX), urease, chymotrypsin and α-glucosidase. The synthesized compounds were also studied by hemolytic method for their cytotoxicity and found to be low-toxicity substances. For AChE inhibition, compound 2 showed IC50 = 31.22 ± 0.45 μM, as compared to compound 1with IC50 = 36.52 ± 0.44 μM. Both compounds showed comparably low activity against BChE and were also active against urease, but compound 1 exhibited selective anti-urease activity. The anti-α-glucosidase activity of both compounds was comparable with that of standard drug used.
Авторлар туралы
Muhammad Akhtar
Department of Chemistry, University of Agriculture
Хат алмасуға жауапты Автор.
Email: nadeemchem@yahoo.com
Пәкістан, Faisalabad
Muhammad Shahid
Department of Biochemistry, University of Agriculture
Email: nadeemchem@yahoo.com
Пәкістан, Faisalabad
Masaaki Sadakiyo
International Institute for Carbon-Neutral Energy Research (I2CNER), Kyushu University
Email: nadeemchem@yahoo.com
Жапония, 744 Moto-oka Nishi-ku, Fukuoka, 819–0395
Muhammad Ikram
Department of Chemistry, Abdul Wali Khan University
Email: nadeemchem@yahoo.com
Пәкістан, Mardan
Sadia Rehman
Department of Chemistry, Abdul Wali Khan University
Email: nadeemchem@yahoo.com
Пәкістан, Mardan
Irshad Ahmed
Department of Pharmacy, The Islamia University of Bahawalpur
Email: nadeemchem@yahoo.com
Пәкістан, Bahawalpur