Technological Aspects of Ensuring the Specific Safety of Human Immunoglobulin and Albumin Preparations
- Authors: Kornilova O.G.1, Krivykh M.A.1, Kudasheva É.Y.1, Borisevich I.V.1
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Affiliations:
- Scientific Centre for Expert Evaluation of Medicinal Products, Ministry of Health of the Russian Federation
- Issue: Vol 52, No 5 (2018)
- Pages: 473-477
- Section: Article
- URL: https://journals.rcsi.science/0091-150X/article/view/245256
- DOI: https://doi.org/10.1007/s11094-018-1842-1
- ID: 245256
Cite item
Abstract
Modern technological approaches to ensuring the specific safety of human immunoglobulin and albumin preparations are analyzed. Introduction into human immunoglobulin preparation technology of donor screening for group- and rhesus-affiliations and chromatographic purification steps to reduce the contents of anti-A and anti-B hemagglutinins and anti-D antibodies are shown to be promising. Technological capabilities for reducing the anticomplementary activity and thrombogenic potential of immunoglobulin preparations and decreasing the contents of prekallikrein activator in human i.v. immunoglobulin and albumin preparations are discussed.
About the authors
O. G. Kornilova
Scientific Centre for Expert Evaluation of Medicinal Products, Ministry of Health of the Russian Federation
Email: chem@folium.ru
Russian Federation, 8/2 Petrovskii Blvd., Moscow, 127051
M. A. Krivykh
Scientific Centre for Expert Evaluation of Medicinal Products, Ministry of Health of the Russian Federation
Email: chem@folium.ru
Russian Federation, 8/2 Petrovskii Blvd., Moscow, 127051
É. Y. Kudasheva
Scientific Centre for Expert Evaluation of Medicinal Products, Ministry of Health of the Russian Federation
Email: chem@folium.ru
Russian Federation, 8/2 Petrovskii Blvd., Moscow, 127051
I. V. Borisevich
Scientific Centre for Expert Evaluation of Medicinal Products, Ministry of Health of the Russian Federation
Email: chem@folium.ru
Russian Federation, 8/2 Petrovskii Blvd., Moscow, 127051