Antidyslipidemic and Antioxidant Effects of Novel Hydroxytriazenes
- Authors: Regar M.1, Baroliya P.K.1, Patidar A.1, Dashora R.1, Mehta A.1, Chauhan R.S.1, Goswami A.K.1
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Affiliations:
- Coordination Chemistry Lab, Department of Chemistry, Mohanlal Sukhadia University
- Issue: Vol 50, No 5 (2016)
- Pages: 310-314
- Section: Article
- URL: https://journals.rcsi.science/0091-150X/article/view/244375
- DOI: https://doi.org/10.1007/s11094-016-1442-x
- ID: 244375
Cite item
Abstract
In the present investigation, a series of substituted hydroxytriazenes containing trifluoromethyl group were synthesized via diazocoupling reaction with phenylhydroxylamine. The structure of synthesized hydroxytriazenes has been assigned on the basis of elemental analysis, IR, 1H NMR and mass spectroscopy data. The lipid lowering effect of synthesized compounds was evaluated on triton-induced hyperlipidemia model in adult male Charles Foster rats. Administration of 400 mg/kg body wt. dose of triton WR 1339 causes elevation in total cholesterol, phospholipid, and triglyceride levels and inhibits post-heparin lipolytic activity, which was reversed by hydroxytriazenes. Adose of 100 mg/kg body wt. also inhibits free radical generation of superoxide anions and hydroxyl radicals and lipid oxidation.
Keywords
About the authors
Mangilal Regar
Coordination Chemistry Lab, Department of Chemistry, Mohanlal Sukhadia University
Email: pbaroliya@yahoo.com
India, Udaipur
P. K. Baroliya
Coordination Chemistry Lab, Department of Chemistry, Mohanlal Sukhadia University
Author for correspondence.
Email: pbaroliya@yahoo.com
India, Udaipur
Ashok Patidar
Coordination Chemistry Lab, Department of Chemistry, Mohanlal Sukhadia University
Email: pbaroliya@yahoo.com
India, Udaipur
Rekha Dashora
Coordination Chemistry Lab, Department of Chemistry, Mohanlal Sukhadia University
Email: pbaroliya@yahoo.com
India, Udaipur
Anita Mehta
Coordination Chemistry Lab, Department of Chemistry, Mohanlal Sukhadia University
Email: pbaroliya@yahoo.com
India, Udaipur
R. S. Chauhan
Coordination Chemistry Lab, Department of Chemistry, Mohanlal Sukhadia University
Email: pbaroliya@yahoo.com
India, Udaipur
A. K. Goswami
Coordination Chemistry Lab, Department of Chemistry, Mohanlal Sukhadia University
Email: pbaroliya@yahoo.com
India, Udaipur