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Interval inhalation application of an oxygen-helium mixture reverses the effects of cerebral arterial air embolism
- Authors: Palikov V.A.1,2, Pavlov N.B.1, Ismailova A.M.2, Amirov R.R.1, Dyachenko I.A.2, Borozdina N.A.2, Bervinova A.V.2, Logunov A.T.3, Murashev A.N.2, Baranov V.M.1
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Affiliations:
- Institute of Biomedical Problems of the Russian Academy of Sciences
- Branch of the Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences
- Closed joint stock company «Specialized Design Bureau of Experimental Equipment at the Institute oof Medical and Biological Problems of the Russian Academy of Sciences»
- Issue: Vol 74, No 5 (2024)
- Pages: 632-637
- Section: ФИЗИОЛОГИЧЕСКИЕ МЕХАНИЗМЫ ПОВЕДЕНИЯ ЖИВОТНЫХ: ВОСПРИЯТИЕ ВНЕШНИХ СТИМУЛОВ, ДВИГАТЕЛЬНАЯ АКТИВНОСТЬ, ОБУЧЕНИЕ И ПАМЯТЬ
- URL: https://journals.rcsi.science/0044-4677/article/view/271515
- DOI: https://doi.org/10.31857/S0044467724050072
- ID: 271515
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Abstract
Oxygen-helium mixture demonstrates marked efficacy of helium mixtures in animal models of ischemia/reperfusion, which opens the possibility of its use as an emergency measure for therapy of vascular embolism. We modelled cerebral arterial air embolism by injecting an air bubble into the internal carotid artery of awake rats. Inhalation of a heated oxygen-helium mixture immediately after modelling arterial embolism normalizes physiological abnormalities and prevents ischemic brain damage, whereas application of a heated oxygen-helium mixture 2 hours after modelling arterial embolism significantly worsens the condition of the animals.
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About the authors
V. A. Palikov
Institute of Biomedical Problems of the Russian Academy of Sciences; Branch of the Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences
Email: baranov-vm@mail.ru
Russian Federation, Moscow; Pushchino
N. B. Pavlov
Institute of Biomedical Problems of the Russian Academy of Sciences
Email: baranov-vm@mail.ru
Russian Federation, Moscow
A. M. Ismailova
Branch of the Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences
Email: baranov-vm@mail.ru
Russian Federation, Pushchino
R. R. Amirov
Institute of Biomedical Problems of the Russian Academy of Sciences
Email: baranov-vm@mail.ru
Russian Federation, Moscow
I. A. Dyachenko
Branch of the Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences
Email: baranov-vm@mail.ru
Russian Federation, Pushchino
N. A. Borozdina
Branch of the Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences
Email: baranov-vm@mail.ru
Russian Federation, Pushchino
A. V. Bervinova
Branch of the Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences
Email: baranov-vm@mail.ru
Russian Federation, Pushchino
A. T. Logunov
Closed joint stock company «Specialized Design Bureau of Experimental Equipment at the Institute oof Medical and Biological Problems of the Russian Academy of Sciences»
Email: baranov-vm@mail.ru
Russian Federation, Khimki
A. N. Murashev
Branch of the Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences
Email: baranov-vm@mail.ru
Russian Federation, Pushchino
V. M. Baranov
Institute of Biomedical Problems of the Russian Academy of Sciences
Author for correspondence.
Email: baranov-vm@mail.ru
Russian Federation, Moscow
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