ASSOCIATION OF THE  ZNF804A rs1344706  GENE POLYMORPHISM WITH THE INDUCED EEG RHYTHMS IN VISUAL PERCEPTION OF THE VERBAL STIMULI IN HEALTHY SUBJECTS AND IN SCHIZOPHRENIA

Zh. V. Garakh; Гарах Ж. В.; V. E. Golimbet; Голимбет В. Е.; E. V. Larionova; Ларионова Е. В.; T. V. Lezheiko; Лежейко Т. В.; V. B. Strelets; Стрелец В. Б.; Yu. Zaytseva; Зайцева Ю. С.

doi:10.31857/S0044467723010070

ASSOCIATION OF THE ZNF804A rs1344706 GENE POLYMORPHISM WITH THE INDUCED EEG RHYTHMS IN VISUAL PERCEPTION OF THE VERBAL STIMULI IN HEALTHY SUBJECTS AND IN SCHIZOPHRENIA

Authors: Garakh Z.V.¹, Golimbet V.E.², Larionova E.V.¹, Lezheiko T.V.², Strelets V.B.¹, Zaytseva Y.³^,4
Affiliations:
1. Institute of Higher Nervous Activity and Neurophysiology Russian Academy of Science
2. Mental Health Research Center
3. National Institute of Mental Health
4. 3rd Faculty of Medicine, Charles University in Prague
Issue: Vol 73, No 1 (2023)
Pages: 38-51
Section: ФИЗИОЛОГИЯ ВЫСШЕЙ НЕРВНОЙ (КОГНИТИВНОЙ) ДЕЯТЕЛЬНОСТИ ЧЕЛОВЕКА
URL: https://journals.rcsi.science/0044-4677/article/view/136076
DOI: https://doi.org/10.31857/S0044467723010070
EDN: https://elibrary.ru/GJGLQN
ID: 136076

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Abstract

We studied the relationship between the ZNF804A rs1344706 gene polymorphism and the parameters of event-related synchronization/desynchronization of EEG rhythms in visual perception of semantic and meaningless verbal information in patients with schizophrenia and schizophrenia spectrum disorders (n = 93) and mentally healthy subjects (n = 93). When reading verbal information regardless of psychiatric status, the theta rhythm synchronization was less pronounced in subjects with the AA genotype than in carriers of allele C. In healthy subjects, the carriers of the AA genotype, in comparison with carriers of allele C, the synchronization of theta rhythm in the posterior cortical areas of the left hemisphere was reduced, and there were no differences in the synchronization of gamma and desynchronization of mu rhythms when perceiving semantic and nonsensical verbal information. In patients with genotype AA, compared with carriers of allele C, the desynchronization of mu rhythm was smaller, which correlated with the severity of poverty of speech on the PANSS scale. The study results indicate a modulating effect of the rs1344706 polymorphism of the ZNF804A gene on the neurophysiological characteristics of the reading process and its contribution to the variability of clinically expressed language disorders.

Keywords

gene ZNF804A, theta-rhythm, gamma-rhythm, mu-rhythm, EEG, schizophrenia, reading

References

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