Enviar artigo por via de e-mail Bromination of 1(9)H-2,3-dihydroimidazo[1,2-a]benzimidazole and its N-derivatives
- Autores: Sochnev V.1, Koshchienko Y.1, Kuz'menko T.1, Kolodina A.1, Borodkin G.1, Morkovnik A.1
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Afiliações:
- Institute of Physical and Organic Chemistry, Southern Federal University
- Edição: Volume 93, Nº 6 (2023)
- Páginas: 858-866
- Seção: Articles
- URL: https://journals.rcsi.science/0044-460X/article/view/145061
- DOI: https://doi.org/10.31857/S0044460X23060045
- EDN: https://elibrary.ru/FKKIWI
- ID: 145061
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Resumo
2,3-Dihydro-1 H -imidazo[1,2- a ]benzimidazole in acetic acid, and its N 1-Me derivative in CHCl3, are brominated at position 6 with bromine. Less nucleophilic N 9-R derivatives do not enter into the reaction under these conditions, but, like their N 1-R isomers, they are quite effectively brominated by the KBrO3-HBr system, but at position 7, probably due to the transition of the reaction to the mode of bromination of protonated forms of substrates. N 1- and N 9-alkyl-6(7)-Br-2,3-dihydroimidazo[1,2- a ]benzimidazoles can also be obtained by N -alkylation of 6(7)-Br-2,3-dihydroimidazo[1,2- a ]benzimidazoles under neutral or basic conditions.
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Sobre autores
V. Sochnev
Institute of Physical and Organic Chemistry, Southern Federal University
Email: vsochnev@sfedu.ru
Yu. Koshchienko
Institute of Physical and Organic Chemistry, Southern Federal University
T. Kuz'menko
Institute of Physical and Organic Chemistry, Southern Federal University
A. Kolodina
Institute of Physical and Organic Chemistry, Southern Federal University
G. Borodkin
Institute of Physical and Organic Chemistry, Southern Federal University
A. Morkovnik
Institute of Physical and Organic Chemistry, Southern Federal University
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