Synthesis and effect of substituted pyrido[2,3-d]pyrimidine-2,4-diones on In Vitro tumor dna methylation

Capa

Citar

Texto integral

Acesso aberto Acesso aberto
Acesso é fechado Acesso está concedido
Acesso é fechado Somente assinantes

Resumo

Reaction of 3-diethylamino-1-aryl-, 3-diethylamino-1-aryl-2-phenyl(4-halophenyl)propane-1-ones hydrochlorides with 6-amino-1,3-dimethyluracil results in heterocyclization products, namely 1,3-dimethyl-7-aryl-5,6dihydro-1 H -pyrido[2,3- d ]pyrimidine-2,4-diones, 1,3-dimethyl-7-aryl-6-phenyl(4-halophenyl)-5,6-dihydro1 H -pyrido[2,3- d ]pyrimidine-2,4-diones and 1,3-dimethyl-7-aryl-6-phenyl-(4-halophenyl)-1 H -pyrido[2,3- d ] pyrimidine-2,4-diones. The effect of the synthesized compounds in vitro tumor DNA methylation was studied.

Sobre autores

A. Isakhanyan

Scientific Technological Center of Organic and Pharmaceutical Chemistry of the National Academy of Sciences of the Republic of Armenia

Email: anush.isakhanyan.51@mail.ru

N. Hakobyan

Scientific Technological Center of Organic and Pharmaceutical Chemistry of the National Academy of Sciences of the Republic of Armenia

Z. Hovasyan

Scientific Technological Center of Organic and Pharmaceutical Chemistry of the National Academy of Sciences of the Republic of Armenia

L. Nersesyan

Scientific Technological Center of Organic and Pharmaceutical Chemistry of the National Academy of Sciences of the Republic of Armenia

A. Aharonyan

Scientific Technological Center of Organic and Pharmaceutical Chemistry of the National Academy of Sciences of the Republic of Armenia

I. Danielyan

Scientific Technological Center of Organic and Pharmaceutical Chemistry of the National Academy of Sciences of the Republic of Armenia

H. Panosyan

Scientific Technological Center of Organic and Pharmaceutical Chemistry of the National Academy of Sciences of the Republic of Armenia

A. Harutyunyan

Scientific Technological Center of Organic and Pharmaceutical Chemistry of the National Academy of Sciences of the Republic of Armenia

Bibliografia

  1. Мещерякова С.А. Дисс. … докт. фарм. наук. Уфа, 2015.
  2. Fares M., Abou-Seri S.M., Abdel-Aziz H.A., Abbas S.E., Youssef M.M., Eladwy R.A. // Eur. J. Med. Chem. 2014. Vol. 83. P. 155. doi: 10.1016/j.ejmech.2014.06.027
  3. Abadi A.H., Hany M.S., Elsharif S.A., Eissa A.A., Gary B.D., Tinsley H.N., Piazza G.A. // Chem. Pharm. Bull. 2013. Vol. 61. N 4. P. 405. doi: 10.1248/cpb.c12-00993
  4. Vanyushin B.F. // JSM Genet. Genomics. 2016. Vol. 3. N 1. P. 1010.
  5. Azad N., Zahnow C.A., Rudin C.M., Baylin S.B. // Nat. Rev. Clin. Oncol. 2013. Vol. 10. N 5. P 256. doi: 10.1038/nrclinonc.2013.42
  6. Геворгян Г.А., Авакян А.П., Агабабян А.Г., Акопян Н.З., Маркарян Т.А., Паносян Г.А. // Хим. ж. Армении. 2013. T. 66. № 4. С. 597.
  7. Baylin S.B., Herman J.G. // Trends Genetics. 2000. Vol. 16. N 4. P. 168.
  8. Howell P.M., Jr., Liu Z., Khong H.T. // Pharmaceuticals. 2010. Vol. 3. N 7. P. 2022. doi: 10.3390/ph3072022
  9. Геворгян Г.А., Авакян А.П., Гаспарян Н.К., Паносян Г.А. // ЖОрХ. 2009. Т. 45. С. 1854
  10. Gevorgyan G.A., Avakyan A.P., Gasparyan N.K., Panosyan G.A. // Russ. J. Org. Chem. 2009. Vol. 45. P. 1853. doi: 10.1134/S1070428009120173
  11. Vanyushin B.F., Masin A.L., Vasiliev V.K., Belozersky A.N. // Biochim. Biophys. Acta. 1973. Vol. 299. N 3. P. 397. doi: 10.1016/0005-2787(73)90264-5

Declaração de direitos autorais © Russian Academy of Sciences, 2023

Este site utiliza cookies

Ao continuar usando nosso site, você concorda com o procedimento de cookies que mantêm o site funcionando normalmente.

Informação sobre cookies