Zinc(II) Complex with 2-Hydroxy-5-ethylphenylphosponic Acid: Synthesis, Structure, Toxicity, and Accumulation in HeLa Cells

Мұқаба

Дәйексөз келтіру

Толық мәтін

Ашық рұқсат Ашық рұқсат
Рұқсат жабық Рұқсат берілді
Рұқсат жабық Тек жазылушылар үшін

Аннотация

A complex of zinc(II) with 2-hydroxy-5-ethylphenylphosphonic acid (H3L) of the composition [Zn(H2L)2(Н2О)2][Zn(HL)(Н2О)]·H2O (I) was synthesized, the structure of which was established based on data of X-ray diffraction and elemental analysis, quantum chemical calculations, as well as IR and electron absorption spectroscopies. The stability constants of H3L acid complexes with zinc(II) perchlorate in water were determined by potentiometric titration. The cytotoxic properties of H3L acid and complex I were studied for the first time on HeLa cells (human cervical adenocarcinoma). The results on the accumulation of complex I in HeLa cells were obtained by laser confocal microscopy.

Авторлар туралы

I. Ivanova

Kurnakov Institute of General and Inorganic Chemistry, Russian Academy of Sciences

Email: tsebrikova@yandex.ru
119991, Moscow, Russia

G. Tsebrikova

Frumkin Institute of Physical Chemistry and Electrochemistry, Russian Academy of Sciences

Email: tsebrikova@yandex.ru
119071, Moscow, Russia

A. Ilyukhin

Kurnakov Institute of General and Inorganic Chemistry, Russian Academy of Sciences

Email: tsebrikova@yandex.ru
119991, Moscow, Russia

V. Solov’ev

Frumkin Institute of Physical Chemistry and Electrochemistry, Russian Academy of Sciences

Email: tsebrikova@yandex.ru
119071, Moscow, Russia

M. Lapshina

Institute of Physiologically Active Substances, Federal Research Center for Problems of Chemical Physics and Medicinal Chemistry, Russian Academy of Sciences

Email: tsebrikova@yandex.ru
142432, Chernogolovka, Moscow oblast, Russia

Yu. Rogacheva

Institute of Physiologically Active Substances, Federal Research Center for Problems of Chemical Physics and Medicinal Chemistry, Russian Academy of Sciences

Email: tsebrikova@yandex.ru
142432, Chernogolovka, Moscow oblast, Russia

E. Pyatova

Kurnakov Institute of General and Inorganic Chemistry, Russian Academy of Sciences

Email: tsebrikova@yandex.ru
119991, Moscow, Russia

V. Baulin

Institute of Physiologically Active Substances, Federal Research Center for Problems of Chemical Physics and Medicinal Chemistry, Russian Academy of Sciences

Email: tsebrikova@yandex.ru
142432, Chernogolovka, Moscow oblast, Russia

A. Tsivadze

Frumkin Institute of Physical Chemistry and Electrochemistry, Russian Academy of Sciences

Хат алмасуға жауапты Автор.
Email: tsebrikova@yandex.ru
119071, Moscow, Russia

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© И.С. Иванова, Г.С. Цебрикова, А.Б. Илюхин, В.П. Соловьев, М.А. Лапшина, Ю.И. Рогачева, Е.Н. Пятова, В.Е. Баулин, А.Ю. Цивадзе, 2023

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