Zinc(II) Complex with 2-Hydroxy-5-ethylphenylphosponic Acid: Synthesis, Structure, Toxicity, and Accumulation in HeLa Cells
- Авторлар: Ivanova I.1, Tsebrikova G.2, Ilyukhin A.1, Solov’ev V.2, Lapshina M.3, Rogacheva Y.3, Pyatova E.1, Baulin V.3, Tsivadze A.2
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Мекемелер:
- Kurnakov Institute of General and Inorganic Chemistry, Russian Academy of Sciences
- Frumkin Institute of Physical Chemistry and Electrochemistry, Russian Academy of Sciences
- Institute of Physiologically Active Substances, Federal Research Center for Problems of Chemical Physics and Medicinal Chemistry, Russian Academy of Sciences
- Шығарылым: Том 68, № 8 (2023)
- Беттер: 1066-1076
- Бөлім: КООРДИНАЦИОННЫЕ СОЕДИНЕНИЯ
- URL: https://journals.rcsi.science/0044-457X/article/view/136408
- DOI: https://doi.org/10.31857/S0044457X23600597
- EDN: https://elibrary.ru/MYBLVM
- ID: 136408
Дәйексөз келтіру
Аннотация
A complex of zinc(II) with 2-hydroxy-5-ethylphenylphosphonic acid (H3L) of the composition [Zn(H2L)2(Н2О)2][Zn(HL)(Н2О)]·H2O (I) was synthesized, the structure of which was established based on data of X-ray diffraction and elemental analysis, quantum chemical calculations, as well as IR and electron absorption spectroscopies. The stability constants of H3L acid complexes with zinc(II) perchlorate in water were determined by potentiometric titration. The cytotoxic properties of H3L acid and complex I were studied for the first time on HeLa cells (human cervical adenocarcinoma). The results on the accumulation of complex I in HeLa cells were obtained by laser confocal microscopy.
Авторлар туралы
I. Ivanova
Kurnakov Institute of General and Inorganic Chemistry, Russian Academy of Sciences
Email: tsebrikova@yandex.ru
119991, Moscow, Russia
G. Tsebrikova
Frumkin Institute of Physical Chemistry and Electrochemistry, Russian Academy of Sciences
Email: tsebrikova@yandex.ru
119071, Moscow, Russia
A. Ilyukhin
Kurnakov Institute of General and Inorganic Chemistry, Russian Academy of Sciences
Email: tsebrikova@yandex.ru
119991, Moscow, Russia
V. Solov’ev
Frumkin Institute of Physical Chemistry and Electrochemistry, Russian Academy of Sciences
Email: tsebrikova@yandex.ru
119071, Moscow, Russia
M. Lapshina
Institute of Physiologically Active Substances, Federal Research Center for Problems of Chemical Physics and Medicinal Chemistry, Russian Academy of Sciences
Email: tsebrikova@yandex.ru
142432, Chernogolovka, Moscow oblast, Russia
Yu. Rogacheva
Institute of Physiologically Active Substances, Federal Research Center for Problems of Chemical Physics and Medicinal Chemistry, Russian Academy of Sciences
Email: tsebrikova@yandex.ru
142432, Chernogolovka, Moscow oblast, Russia
E. Pyatova
Kurnakov Institute of General and Inorganic Chemistry, Russian Academy of Sciences
Email: tsebrikova@yandex.ru
119991, Moscow, Russia
V. Baulin
Institute of Physiologically Active Substances, Federal Research Center for Problems of Chemical Physics and Medicinal Chemistry, Russian Academy of Sciences
Email: tsebrikova@yandex.ru
142432, Chernogolovka, Moscow oblast, Russia
A. Tsivadze
Frumkin Institute of Physical Chemistry and Electrochemistry, Russian Academy of Sciences
Хат алмасуға жауапты Автор.
Email: tsebrikova@yandex.ru
119071, Moscow, Russia
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