Antioxidant Activity of Conjugates of Cerium Dioxide Nanoparticles with Human Serum Albumin Isolated from Biological Fluids

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Abstract

For the first time, an analysis was made of the antioxidant properties of conjugates of CeO2 nanoparticles with human serum albumin (CeO2@HSA), including HSA isolated from blood plasma and biological fluids similar in composition to blood plasma, namely, peritoneal (ascitic) and synovial (articular) fluids. The antioxidant activity of hybrid nanomaterials was studied in relation to alkylperoxyl radicals by luminol-dependent chemiluminescence. It was shown that the interaction of CeO2 nanoparticles with purified human serum albumin is accompanied by a decrease in the antioxidant and prooxidant potential of albumin by a factor of ⁓1.5. Presumably, this is caused by the interaction of nanodispersed CeO2 with sulfhydryl groups of the protein. Conjugates of CeO2 nanoparticles with albumin isolated from biological fluids (CeO2@HSA) exhibit a synergistic antioxidant effect. In this case, the mechanism of antioxidant activity is fundamentally different from that for CeO2 sols modified with purified human serum albumin. According to quantitative assessment, the antioxidant capacity of CeO2@HSA conjugates is ⁓20 times lower than that of Trolox, a water-soluble analog of vitamin E.

About the authors

M. M. Sozarukova

Kurnakov Institute of General and Inorganic Chemistry, Russian Academy of Sciences

Email: S_MadinaM@bk.ru
119991, Moscow, Russia

E. V. Proskurnina

Research Centre for Medical Genetics

Email: S_MadinaM@bk.ru
115522, Moscow, Russia

A. E. Baranchikov

Kurnakov Institute of General and Inorganic Chemistry, Russian Academy of Sciences

Email: S_MadinaM@bk.ru
119991, Moscow, Russia

V. K. Ivanov

Kurnakov Institute of General and Inorganic Chemistry, Russian Academy of Sciences

Author for correspondence.
Email: S_MadinaM@bk.ru
119991, Moscow, Russia

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