On the Interaction of Gold(III) Complexes with Human Serum Albumin
- Authors: Mironov I.V.1, Kharlamova V.Y.1
-
Affiliations:
- Nikolaev Institute of Inorganic Chemistry, Siberian Branch, Russian Academy of Sciences
- Issue: Vol 68, No 10 (2023)
- Pages: 1495-1503
- Section: ФИЗИКОХИМИЯ РАСТВОРОВ
- URL: https://journals.rcsi.science/0044-457X/article/view/140317
- DOI: https://doi.org/10.31857/S0044457X23600639
- EDN: https://elibrary.ru/LSVTRF
- ID: 140317
Cite item
Abstract
The interaction of gold(III) complexes (Au(bipy)
, Au(phen)
, and Au(dien-H)Cl+) with human serum albumin (HSA) was studied in aqueous solutions (pH 7.4, CNaCl = 0.2 M, CAu = (2–10) × 10–5 M, CHSA < 6 × 10–4 M) at 25°C. In all cases, gold(III) is reduced to gold(I), which forms a complex with HSA. When an excess of HSA is present, the time required for complete transformation of the complexes does not exceed 1 h. In addition, it was shown that the redox reaction of gold(III) complexes with cysteine is much faster than the reaction with methionine.
Keywords
About the authors
I. V. Mironov
Nikolaev Institute of Inorganic Chemistry, Siberian Branch, Russian Academy of Sciences
Email: imir@niic.nsc.ru
630090, Novosibirsk, Russia
V. Yu. Kharlamova
Nikolaev Institute of Inorganic Chemistry, Siberian Branch, Russian Academy of Sciences
Author for correspondence.
Email: imir@niic.nsc.ru
630090, Novosibirsk, Russia
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