Relationships of Enantioselective Retention of Chiral Oxazolopyrroloquinolones on a Stationary Phase with Grafted Ristocetin А Antibiotic from Aqueous Methanol Solutions
- Authors: Stepanova M.V.1, Asnin L.D.1, Boteva A.A.1
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Affiliations:
- Perm National Research Polytechnical University
- Issue: Vol 97, No 2 (2023)
- Pages: 293-300
- Section: ФИЗИЧЕСКАЯ ХИМИЯ ПРОЦЕССОВ РАЗДЕЛЕНИЯ. ХРОМАТОГРАФИЯ
- URL: https://journals.rcsi.science/0044-4537/article/view/136532
- DOI: https://doi.org/10.31857/S0044453723020280
- EDN: https://elibrary.ru/ELTCCV
- ID: 136532
Cite item
Abstract
The mechanisms of retention and separation of the enantiomers of chiral oxazolopyrroloquinolones on a stationary phase with graftеd macrocyclic antibiotic ristocetin A under conditions of high-performance liquid chromatography with aqueous methanol mobile phases have been studied. The retention factor was found to decrease monotonically when the CH3OH concentration in the mobile phase increased to 90 vol %; then it slightly increased as the composition of the mobile phase approached pure methanol. The thermodynamics of adsorption of oxazolopyrroloquinolones in different regions of this dependence was studied. A mathematical model has been proposed; it describes well the experimental data and allows for analyte solvation in the mobile phase and competitive adsorption (with mobile phase components) on a chiral selector. The results were compared with previously obtained data for water–acetonitrile mobile phases. The reasons for the observed differences were discussed.
About the authors
M. V. Stepanova
Perm National Research Polytechnical University
Email: asninld@mail.ru
614990, Perm, Russia
L. D. Asnin
Perm National Research Polytechnical University
Email: asninld@mail.ru
614990, Perm, Russia
A. A. Boteva
Perm National Research Polytechnical University
Author for correspondence.
Email: asninld@mail.ru
614990, Perm, Russia
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