Interaction between Iron Nitrosyl Complexes and Phosphatidylcholine Membranes: A Fluorescence Study
- 作者: Poletaeva D.1, Faingold I.1, Soldatova Y.1, Smolina A.1, Savushkin M.2, Sanina N.1,3, Aldoshin S.1
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隶属关系:
- Federal Research Center of Problems of Chemical Physics and Medicinal Chemistry, Russian Academy of Sciences
- Faculty of Chemistry, Moscow State University
- Medicinal Chemistry Research and Educational Center
- 期: 卷 97, 编号 5 (2023)
- 页面: 617-623
- 栏目: ФИЗИКА И ХИМИЯ ЭЛЕМЕНТАРНЫХ ХИМИЧЕСКИХ ПРОЦЕССОВ
- URL: https://journals.rcsi.science/0044-4537/article/view/136567
- DOI: https://doi.org/10.31857/S0044453723050217
- EDN: https://elibrary.ru/HLWJUG
- ID: 136567
如何引用文章
详细
Fluorescent probes: 8-anilino-1-naphthalenesulfonate (ANS), eosin Y, and pyrene were used to study the interaction between liposomes and three nitrosyl iron complexes that are promising anti-inflammatory agents and cardioprotectors. It was shown that the studied complexes compete with ANS molecules for the bonding sites in a bilayer of liposomes. The incorporation of the complexes into the lipid bilayer was also studied according to the quenching of eosin Y and pyrene fluorescence. The data suggest that iron nitrosyl complexes interact with the phospholipids headgroups and can penetrate deeper into the hydrophobic center of a lipid bilayer, where they affect the packing of fatty acid chains. The pronounced membranotropic properties of the complexes correlated with their ability to inhibit lipid peroxidation. Complexes with high constants of pyrene bonding are the most effective antioxidants.
作者简介
D. Poletaeva
Federal Research Center of Problems of Chemical Physics and Medicinal Chemistry, Russian Academy of Sciences
Email: dapol@icp.ac.ru
142432, Chernogolovka, Moscow oblast, Russia
I. Faingold
Federal Research Center of Problems of Chemical Physics and Medicinal Chemistry, Russian Academy of Sciences
Email: dapol@icp.ac.ru
142432, Chernogolovka, Moscow oblast, Russia
Yu. Soldatova
Federal Research Center of Problems of Chemical Physics and Medicinal Chemistry, Russian Academy of Sciences
Email: dapol@icp.ac.ru
142432, Chernogolovka, Moscow oblast, Russia
A. Smolina
Federal Research Center of Problems of Chemical Physics and Medicinal Chemistry, Russian Academy of Sciences
Email: dapol@icp.ac.ru
142432, Chernogolovka, Moscow oblast, Russia
M. Savushkin
Faculty of Chemistry, Moscow State University
Email: dapol@icp.ac.ru
119991, Moscow, Russia
N. Sanina
Federal Research Center of Problems of Chemical Physics and Medicinal Chemistry, Russian Academy of Sciences; Medicinal Chemistry Research and Educational Center
Email: dapol@icp.ac.ru
142432, Chernogolovka, Moscow oblast, Russia; 119991, Moscow, Russia
S. Aldoshin
Federal Research Center of Problems of Chemical Physics and Medicinal Chemistry, Russian Academy of Sciences
编辑信件的主要联系方式.
Email: dapol@icp.ac.ru
142432, Chernogolovka, Moscow oblast, Russia
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