MECHANISMS OF SYNAPTIC VESICLE RECYCLING IN CENTRAL SYNAPSES: NEW FACTS AND UNRESOLVED PROBLEMS

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Abstract

During synaptic activity, neurotransmitter-filled secretory vesicles fuse with the presynaptic membrane at the active zone in interneuronal synapses to release their content into the synaptic cleft. Following this release, the synaptic vesicle pool is restored by different endocytic mechanisms, including clathrin-mediated endocytosis, “kiss-and-run” or “kiss-shrink-run” endocytosis, superfast endocytosis, and bulk endocytosis. Recent studies identified many molecules involved in these endocytic pathways and uncovered the key molecular interactions guiding each of these mechanisms. Furthermore, results of several investigations suggest links between the perturbations of molecular interactions during synaptic vesicle recycling and neurological diseases. These interactions may serve as molecular targets for the development of therapies to cure these diseases.

About the authors

N. V. Nifantova

Sechenov's Institute of Evolutionary Physiology and Biochemistry

St.-Petersburg, Russia

D. A. Sibarov

Sechenov's Institute of Evolutionary Physiology and Biochemistry

Email: dsibarov@gmail.com
St.-Petersburg, Russia

O. V. Shupliakov

Sechenov's Institute of Evolutionary Physiology and Biochemistry; St.-Petersburg State University, Institute of Translational Biomedicine; Karolinska Institutet

Email: oleg.shupliakov@ki.se
St.-Petersburg, Russia; St. Petersburg, Russia; Stockholm, Sweden

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