BILATERAL SYNCHRONIZATION OF HIPPOCAMPAL THETA-OSCILLATIONS IN VITRO
- 作者: Khalilov I.1,2, Gainutdinov A.1, Khazipov R.1,2
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隶属关系:
- Aix-Marseille University, INMED, INSERM
- Laboratory of Neurobiology, Kazan Federal University
- 期: 卷 59, 编号 3 (2023)
- 页面: 207-214
- 栏目: ЭКСПЕРИМЕНТАЛЬНЫЕ СТАТЬИ
- URL: https://journals.rcsi.science/0044-4529/article/view/136699
- DOI: https://doi.org/10.31857/S004445292303004X
- EDN: https://elibrary.ru/YHGGYA
- ID: 136699
如何引用文章
详细
Hippocampal theta oscillations are pivotal for hippocampal functions of spatial navigation, learning and memory. In the behaving animals in vivo, hippocampal theta oscillations display bilateral synchronization. Internally generated oscillations in the theta frequency range have also been described in the intact hippocampus preparation in vitro. How theta oscillations are synchronized between the left and right hippocampi remains elusive, however. We used preparation of the intact hippocampi interconnected by the ventral hippocampal commissure prepared from juvenile and adult mice and rats in vitro. Local field potentials and multiunit activity were recorded using extracellular electrodes from the pyramidal cell layer and stratum radiatum of the left and right hippocampi. Neuronal network activity in the left and right hippocampi was organized in theta oscillations, which strongly modulated neuronal firing of CA1 neurons. Both neuronal activity and field potential theta oscillations showed high levels of bilateral synchronization. Theta oscillations persisted on both sides, but their bilateral synchronization was eliminated after surgical cut of the ventral hippocampal commissure. Thus, theta oscillations are synchronized in the left and right hippocampi in vitro, and their bilateral synchronization is provided by the ventral commissural connections.
作者简介
I. Khalilov
Aix-Marseille University, INMED, INSERM; Laboratory of Neurobiology, Kazan Federal University
Email: roustem.khazipov@inserm.fr
France, Marseille; Russia, Kazan
A. Gainutdinov
Aix-Marseille University, INMED, INSERM
Email: roustem.khazipov@inserm.fr
France, Marseille
R. Khazipov
Aix-Marseille University, INMED, INSERM; Laboratory of Neurobiology, Kazan Federal University
编辑信件的主要联系方式.
Email: roustem.khazipov@inserm.fr
France, Marseille; Russia, Kazan
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