Improvement of selectivity and sensitivity of tetracycline antibiotics analysis based on ESI-MS method with monoquadrople mass analyser

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Abstract

Methodological approaches that can be applied to improve the metrological characteristics of a monoquadrupole mass analyser for the study of residual content of small organic substances in aqueous media on the example of tetracycline antibiotics are described. To improve the selectivity of the analysis it is suggested to use optimal parameters of electron optics in the source (voltage at the fragmentor) in order to achieve high yield of ion-products. It is shown that the sensitivity of the analysis can be improved by summing the signals of all formed ion-products.

About the authors

A. V. Streletskiy

Center for Strategic Planning and Management of Medical and Biological Health Risks of the Federal Medical and Biological Agency

Email: AStreletsky@cspfmba.ru
Moscow, Russia

N. S. Antropova

Center for Strategic Planning and Management of Medical and Biological Health Risks of the Federal Medical and Biological Agency

Author for correspondence.
Email: AStreletsky@cspfmba.ru
Moscow, Russia

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