A Voltammetric Sensor Based on Aluminophosphate Zeolite and a Composite of Betulinic Acid with a Chitosan Polyelectrolyte Complex for the Identification and Determination of Naproxen Enantiomers

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Abstract

A voltammetric sensor was developed based on a glassy carbon electrode with aluminophosphate zeolite finely dispersed on its surface, modified with a polyelectrolyte complex of chitosan with succinyl chitosan and betulinic acid, for the selective detection and determination of naproxen enantiomers. The electrochemical and analytical characteristics of the sensor were studied, and the effective electrode surface area (A = 9.8 ± 0.5 mm2) and charge transfer resistance (Ret = 649.9 ± 0.4 Ω) were calculated. In determining naproxen enantiomers, calibration characteristics are linear in the range from 2.5 × 10–5 to 1 × 10–3 M with limits of detection of 1.1 × 10–7 and 1.5 × 10–7 M and limits of quantification of 3.6 × 10–7 and 4.9 × 10–7 M for R- and S-naproxen, respectively. The sensor is more sensitive to R-naproxen (∆Ep = 60 mV, ipR/ipS = 1.40). The proposed sensor was used to recognize and determine naproxen enantiomers in human urine and plasma samples. Statistical evaluation of the results by the standard addition method showed that there was no systematic error.

About the authors

R. A. Zilberg

Department of Chemistry, Ufa University of Science and Technology

Email: ZilbergRA@yandex.ru
450076, Ufa, Bashkortostan, Russia

V. N. Maistrenko

Department of Chemistry, Ufa University of Science and Technology

Email: ZilbergRA@yandex.ru
450076, Ufa, Bashkortostan, Russia

Yu. V. Teres

450076, Ufa, Bashkortostan, Russia

Email: ZilbergRA@yandex.ru
450076, Ufa, Bashkortostan, Russia

I. V. Vakulin

Department of Chemistry, Ufa University of Science and Technology

Email: ZilbergRA@yandex.ru
450076, Ufa, Bashkortostan, Russia

E. O. Bulysheva

Department of Chemistry, Ufa University of Science and Technology

Email: ZilbergRA@yandex.ru
450076, Ufa, Bashkortostan, Russia

A. A. Seluyanova

Department of Chemistry, Ufa University of Science and Technology

Author for correspondence.
Email: ZilbergRA@yandex.ru
450076, Ufa, Bashkortostan, Russia

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Copyright (c) 2023 Р.А. Зильберг, В.Н. Майстренко, Ю.Б. Терес, И.В. Вакулин, Е.О. Булышева, А.А. Селуянова

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