Multilayer Coatings Based On Citrate-Stabilized Gold Nanoparticles and Polydiallyldimethylammonium Chloride for the Electrophoretic Separation of Carboxylic Acids

D. V. Makeeva; Макеева Д. В.; K. S. Antipova; Антипова К. С.; E. V. Solovyeva; Соловьева Е. В.; V. P. Morgacheva; Моргачева В. П.; E. A. Kolobova; Колобова Е. А.; L. A. Kartsova; Карцова Л. А.

doi:10.31857/S0044450223030088

Multilayer Coatings Based On Citrate-Stabilized Gold Nanoparticles and Polydiallyldimethylammonium Chloride for the Electrophoretic Separation of Carboxylic Acids

Authors: Makeeva D.V.¹, Antipova K.S.¹, Solovyeva E.V.¹, Morgacheva V.P.¹, Kolobova E.A.¹, Kartsova L.A.¹
Affiliations:
1. St. Petersburg State University
Issue: Vol 78, No 3 (2023)
Pages: 241-252
Section: ОРИГИНАЛЬНЫЕ СТАТЬИ
URL: https://journals.rcsi.science/0044-4502/article/view/136008
DOI: https://doi.org/10.31857/S0044450223030088
EDN: https://elibrary.ru/FUQJKK
ID: 136008

Cite item

Full Text

Open Access
Restricted Access

Access granted
Restricted Access

Subscription Access

Abstract
About the authors
References
Supplementary files
Statistics

Abstract

The conditions for the formation of physically adsorbed three-layer coatings of quartz capillary walls in capillary electrophoresis (CE) with successively deposited oppositely charged layers of polydiallyldimethylammonium chloride (PDADMAC) modifiers and citrate-stabilized gold nanoparticles (GNPs) are proposed. It was shown that three-layer PDADMAC–GNP–PDADMAC coatings favorably differ from monolayer coatings with PDADMAC by greater stability in a wide range of pH (2–10). The formed coatings were characterized by scanning electron microscopy, and the presence of a uniform dense layer of nanoparticles on the capillary surface was confirmed. The applicability of the modified capillaries under CE conditions was demonstrated by the separation of a mixture of 16 carboxylic acids. An increase in the separation selectivity achieved with the use of three-layer coatings based on GNPs was explained by the reversible exchange of citrate anions on the GNP surface with negatively charged analytes in the course of electrophoretic analysis.

Keywords

gold nanoparticles, multilayer coatings, capillary electrophoresis, carboxylic acids

References

Карцова Л.А., Макеева Д.В., Бессонова Е.А. Современное состояние метода капиллярного электрофореза // Журн. аналит. химии. 2020. Т. 12. № 75. С. 1059.
Kartsova L.A., Makeeva D.V., Davankov V.A. Capillary electrophoresis as a powerful tool for the analyses of bacterial samples // Trends Anal. Chem. 2019. V. 120. Article 115656. https://doi.org/10.1016/j.trac.2019.115656
Ban E., Yoo Y.S., Song E.J. Analysis and application of nanoparticles in capillary electrophoresis // Talanta. 2015. V. 141. P. 15. https://doi.org/10.1016/j.talanta.2015.03.020
Zhang Z., Yan B., Liu K., Liao Y., Liu H. CE-MS analysis of heroin and its basic impurities using a charged polymer-protected gold nanoparticle-coated capillary // Electrophoresis. 2009. V. 30. P. 379. https://doi.org/10.1002/elps.200800069
Hamer M., Yone A., Rezzano I. Gold nanoparticle-coated capillaries for protein and peptide analysis on open-tubular capillary electrochromatography // Electrophoresis. 2021. V. 33. P. 334. https://doi.org/10.1002/elps.201100297
Kang H., Buchman J.T., Rodriguez R.S., Ring H.L., He J., Bantz K.C., Haynes C.L. Stabilization of silver and gold nanoparticles: preservation and improvement of plasmonic functionalities // Chem. Rev. 2019. V. 119. № 1. P. 664. https://doi.org/10.1021/acs.chemrev.8b00341
Neiman B., Grushka E., Lev O. Use of gold nanoparticles to enhance capillary electrophoresis // Anal. Chem. 2001. V. 73. P. 5220. https://doi.org/10.1021/ac0104375
Yu C.J., Su C.L., Tseng W.L. Separation of acidic and basic proteins by nanoparticle-filled capillary electrophoresis // Anal. Chem. 2006. V. 78. P. 8004. https://doi.org/10.1021/ac061059c
Subramaniam V., Griffith L., Haes A.J. Varying nanoparticle pseudostationary phase plug length during capillary electrophoresis // Analyst. 2011. V. 136. P. 3469. https://doi.org/10.1039/C1AN15185A
Qu Q., Liu D., Mangelings D., Yang C., Hu X. Permanent gold nanoparticle coatings on polyelectrolyte multilayer modified capillaries for open-tubular capillary electrochromatography // J. Chromatogr. A. 2010. V. 1217. P. 6588. https://doi.org/10.1016/j.chroma.2010.08.057
Robb C.S. Applications of physically adsorbed polymer coatings in capillary electrophoresis // J. Liq. Chromatogr. Relat. Technol. 2007. V. 30. № 5. P. 729. https://doi.org/10.1080/10826070701191029
Morrison D.J., Preston T. Formation of short chain fatty acids by the gut microbiota and their impact on human metabolism // Gut Microbes. 2016. V. 7. P. 189. https://doi.org/10.1080/19490976.2015.1134082
Zhang Q., Niu Y., Lyu W., Yu M. Formic acid up-regulates vascular tension through nitric oxide-cGMP signaling pathway // Chem. Biol. Interact. 2019. V. 309. Article 108710. https://doi.org/10.1016/j.cbi.2019.06.023
Galland L. The gut microbiome and the brain // J. Med. Food. 2014. V. 17. P. 1261. https://doi.org/10.1089/jmf.2014.7000
Frens G. Controlled nucleation for the regulation of the particle size in monodisperse gold suspensions // Nat. Phys. Sci. 1973. V. 241. P. 20.
Polikarpova D., Makeeva D., Kartsova L., Dolgonosov A., Kolotilina N. Nano-sized anion-exchangers as a stationary phase in capillary electrochromatography for separation and on-line concentration of carboxylic acids // Talanta. 2018. V. 188. P. 744. https://doi.org/10.1016/j.talanta.2018.05.094