Miescher granulomatous cheilitis as a monosymptomatic variant of Melkersson–Rosenthal syndrome

Granulomatous cheilitis is a chronic swelling of one or both lips that is caused by granulomatous inflammation. This is a rare inflammatory disease that belongs to the monosymptomatic form of Melkersson–Rosenthal syndrome. To date, the etiology of this disease remains unknown, and its treatment is challenging. The article discusses a case report of a monosymptomatic variant of recurrent orofacial edema, describes the features of the observed case and efficacy of intradermal application of glucocorticosteroids and fractional photothermolysis, and provides data on the differential diagnosis of the disease. This case highlights the importance of thorough examination in the diagnosis process as the clinical presentation can be similar to many other granulomatous conditions.