Experience with isotretinoin-lidose acne therapy

Background. According to the World Health Organization, about 85 % of the global population suffers from acne. Isotretinoin, showing high clinical efficacy, is widely used for the treatment of moderate forms of this disease. This article presents an analysis of the clinical experience with isotretinoin in patients with moderate acne. The use of Lidose innovative patented technology allows for a 20% reduction in the daily dose of the active ingredient without compromising the clinical efficacy of the product which can improve its tolerability and enhance patient compliance.

Aim. To evaluate the clinical efficacy of isotretinoin, developed using Lidose technology, at doses of 8 mg and 16 mg.

Methods. This study analyzed data from 915 patients who received an innovative form of isotretinoin developed using Lidose technology over the past 5 years. All patients were treated for moderate to severe acne. The product dose was 0.4–0.8 mg/kg body weight per day.

Results. Isotretinoin therapy showed high efficacy in the treatment of moderate to severe acne. Clinical remission defined as complete or almost complete resolution of skin rashes (IGA score of 0 or 1) was achieved in 872 patients (95.3%). A significant improvement in skin condition, characterized by reduction in acne severity by ≥ 2 points on the Investigator’s Global Assessment (IGA) scale, was observed in 700 patients (76.4%) after 3 months of therapy. Generally, the number of inflammatory sites (papules, pustules, and nodules) decreased by 89.2% by the end of the treatment course (p < 0.001).

Conclusion. The innovative dosage form of isotretinoin developed using Lidose technology is characterized by high efficacy and good tolerability. This allows to consider it as a full-fledged alternative to the original isotretinoin with optimized bioavailability which ensures therapeutic effect at reduced dosages.