Manifestation of basal cell carcinoma in a 10-year-old child

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Abstract

Basal cell carcinoma is one of the most common types of skin cancer among adults, but in children it is extremely rare and is usually associated with genetic syndromes (for example, Gorlin–Goltz syndrome or xeroderma pigmentosum) or with the consequences of radiation therapy performed in children. We present a clinical case of a 10-year-old child diagnosed with basal cell carcinoma. The child’s parents consented to the publication of the data. A 10-year-old patient, accompanied by his mother, came to the outpatient department of the St. Petersburg Clinical Scientific and Practical Center for Specialized Types of Medical Care (Oncology) named after N.P. Napalkov (KNPC SVMP) with complaints about a formation that was detected 4 months ago and was increasing in size. From the family history it is known that the boy’s mother was diagnosed with Hodgkin’s lymphoma at the age of 13, for which chemoradiotherapy was performed. At the age of 30, she was diagnosed with multiple basal cell carcinomas in the area of radiation.

About the authors

Julia E. Zueva

St. Petersburg Clinical Scientific and Practical Center for Specialized Types of Medical Care (Oncology) named after N.P. Napalkov

Author for correspondence.
Email: yulichka.ch@mail.ru
ORCID iD: 0000-0002-2117-3467

pediatric oncologist

Russian Federation, St. Petersburg

Julia A. Konusova

St. Petersburg Clinical Scientific and Practical Center for Specialized Types of Medical Care (Oncology) named after N.P. Napalkov

Email: change85@mail.ru
ORCID iD: 0009-0005-1336-6700

pediatric oncologist

Russian Federation, St. Petersburg

Eugene V. Pankin

St. Petersburg Clinical Scientific and Practical Center for Specialized Types of Medical Care (Oncology) named after N.P. Napalkov

Email: pankin-evgeniy98@yandex.ru
ORCID iD: 0009-0001-4007-7577

pathologist

Russian Federation, St. Petersburg

Margarita B. Belogurova

St. Petersburg Clinical Scientific and Practical Center for Specialized Types of Medical Care (Oncology) named after N.P. Napalkov

Email: deton.hospital31@inbox.ru
ORCID iD: 0000-0002-7471-7181
SPIN-code: 2627-4152

MD, Dr. Sci. (Med.), Professor

Russian Federation, St. Petersburg

References

  1. Toro JR, Hamouda RS, Bale S. Basal Cell Carcinoma. Encyclopedia of Cancer. 4th ed. Springer; 2017. P. 433–437. doi: 10.1007/978-3-662-46875-3_529
  2. de la Luz Orozco-Covarrubias M, Tamayo-Sanchez L, Duran-McKinster C, Ridaura C, Ruiz-Maldonado R. Malignant cutaneous tumors in children. Twenty years of experience at a large pediatric hospital. J Am Acad Dermatol. 1994;30(2 Pt 1):243–249.
  3. Varan A, Gököz A, Akyüz C, Kutluk T, YalçIn B, Köksal Y, et al. Primary malignant skin tumors in children: etiology, treatment and prognosis. Pediatr Int. 2005;47(6):653–657. doi: 10.1111/j.1442-200x.2005.02145.x
  4. Waldman RA, Grant-Kels JM. Malignant skin tumors: Kids are not just little people. Clin Dermatol. 2017;35(6):517–529. doi: 10.1016/j.clindermatol.2017.08.003
  5. Kuvat SV, Gücin Z, Keklik B, Özyalvaçlı G, Başaran K. Basal Cell Carcinoma in a Child. J Skin Cancer. 2011;2011:752901. doi: 10.1155/2011/752901
  6. Tilli CMLJ, Van Steensel MAM, Krekels GAM, Neumann HAM, Ramaekers FCS. Molecular aetiology and pathogenesis of basal cell carcinoma. Br J Dermatol. 2005;152(6):1108–1124. doi: 10.1111/j.1365-2133.2005.06587.x
  7. Гельфонд М.Л. Дифференциальная диагностика опухолей кожи в практике дерматологов и косметологов. Практическая онкология. 2012;13(2):69–79. [Gelfond ML. Differential diagnostics of skin tumors in the practice of dermatologists and cosmetologists. Practical oncology. 2012;13(2):69–79. (In Russ.)]
  8. Verkouteren BJA, Cosgun B, Reinders MGHC, Kessler PAWK, Vermeulen RJ, Klaassens M, et al. A guideline for the clinical management of basal cell naevus syndrome (Gorlin–Goltz syndrome). Br J Dermatol. 2022;186(2):215–226. doi: 10.1111/bjd.20700
  9. Schierbeck J, Vestergaard T, Bygum A. Skin Cancer Associated Genodermatoses: A Literature Review. Acta Derm Venereol. 2019;99(4):360–369. doi: 10.2340/00015555-3123
  10. Lehmann J, Schubert S, Emmert S. Xeroderma pigmentosum: diagnostic procedures, interdisciplinary patient care, and novel therapeutic approaches. J Dtsch Dermatol Ges. 2014;12(10):867–872. doi: 10.1111/ddg.12419
  11. Cohen PR. Red Dot Basal Cell Carcinoma: Report of Cases and Review of this Unique Presentation of Basal Cell Carcinoma. Cureus. 2017;9(3):e1110. doi: 10.7759/cureus.1110
  12. Гамаюнов С.В., Шумская И.С. Базальноклеточный рак кожи — обзор современного состояния проблемы. Практическая онкология. 2012;13(2):92–106. [Gamayunov SV, Shumskaya IS. Basal cell skin cancer — a review of the current state of the problem. Practical oncology. 2012;13(2):92–106. (In Russ.)]
  13. Stolz W. Dermatoscopy. Braun-Falco´s Dermatology. Springer; 2021. P. 1–8. doi: 10.1007/978-3-662-58713-3_5-1
  14. Scalvenzi M, Lembo S, Francia MG, Balato A. Dermoscopic patterns of superficial basal cell carcinoma. Int J Dermatol. 2008;47(10):1015–1018. doi: 10.1111/j.1365-4632.2008.03731.x
  15. Altamura D, Menzies SW, Argenziano G, Zalaudek I, Soyer HP, Sera F, et al. Dermatoscopy of basal cell carcinoma: Morphologic variability of global and local features and accuracy of diagnosis. J Am Acad Dermatol. 2010;62(1):67–75. doi: 10.1016/j.jaad.2009.05.035
  16. Wennberg AM. Basal cell carcinoma — new aspects of diagnosis and treatment. Acta Derm Venereol Suppl (Stocrh). 2000;209:5–25.

Supplementary files

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2. Fig. 1. Macroscopic picture of basal cell carcinoma of the chest skin in a 10-year-old boy

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3. Fig. 2. Basal cell carcinoma. Green arrow — connection of the tumor with the epidermis; red arrow — slit-like retraction of the stroma; blue arrow — palisade arrangement of basaloid cells; yellow arrow — focus of necrosis. H&E: а — × 40; б — × 100

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Copyright (c) 2025 Zueva J.E., Konusova J.A., Pankin E.V., Belogurova M.B.

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