Experience with the fixed combination of benzoyl peroxide and clindamycin in acne therapy
- Authors: Verchoumova A.A.1, Khairutdinov V.R.1,2, Telichko I.N.2,3
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Affiliations:
- S.M. Kirov Military Medical Academy
- The Institute of Medical Education at the V.A. Almazov Scientific Research Centre
- Dermatovenerological Dispensary No. 4
- Issue: Vol 100, No 1 (2024)
- Pages: 56-62
- Section: ORIGINAL STUDIES
- URL: https://journals.rcsi.science/0042-4609/article/view/254521
- DOI: https://doi.org/10.25208/vdv16050
- ID: 254521
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Abstract
Background. Acne is one of the most common dermatoses, affecting more than 9% of the world’s population. Acne negatively affects the patient’s quality of life and self-esteem, often leading to the development of anxiety and depression. The combination of pharmacological drugs with different mechanisms of action in one external dosage form can provide higher therapeutic efficacy.
Aims. To evaluate the effectiveness and tolerability of a combination drug with a fixed dose of clindamycin 1% and benzoyl peroxide 5% in the treatment of patients with mild to moderate papulopustular acne.
Methods. A single-center, open-label, observational, prospective study lasting 6 weeks was performed, which included 40 patients with mild to moderate papulopustular acne who received a gel with a fixed dose of clindamycin 1% and benzoyl peroxide 5% once a day. A clinical assessment of the effectiveness of therapy was carried out, PH, greasiness and moisture of the facial skin were measured, and the dynamics of the dermatological quality of life index was studied.
Results. The proportion of patients who showed significant improvement at the end of 6 weeks of treatment was 32/40 (80%). The total proportion of patients who showed significant and moderate improvement at the end of therapy reached 36/40 (90%).
Conclusion. The results obtained showed the high therapeutic effectiveness of the gel with a fixed dose of clindamycin 1% and benzoyl peroxide 5% in the treatment of mild to moderate papulopustular acne.
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##article.viewOnOriginalSite##About the authors
Anna A. Verchoumova
S.M. Kirov Military Medical Academy
Author for correspondence.
Email: anna.chernyshova2307@ya.ru
ORCID iD: 0000-0002-3360-2046
MD, Resident
Russian Federation, Saint PetersburgVladislav R. Khairutdinov
S.M. Kirov Military Medical Academy; The Institute of Medical Education at the V.A. Almazov Scientific Research Centre
Email: haric03@list.ru
ORCID iD: 0000-0002-0387-5481
MD, Dr. Sci. (Med.), Assistant Professor
Russian Federation, Saint Petersburg; Saint PetersburgIgor N. Telichko
The Institute of Medical Education at the V.A. Almazov Scientific Research Centre; Dermatovenerological Dispensary No. 4
Email: itelichko@yandex.ru
ORCID iD: 0000-0001-7544-654X
MD, Dr. Sci. (Med.), Professor
Russian Federation, Saint Petersburg; Saint PetersburgReferences
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