A new atypical form of lipoid necrobiosis not associated with diabetes mellitus. Clinical case and a brief review of the literature
- Authors: Cheboksarov D.I.1, Molodykh K.J.1, Monakhov K.N.1, Sokolovskiy E.V.1
-
Affiliations:
- Pavlov First Saint Petersburg State Medical University
- Issue: Vol 99, No 1 (2023)
- Pages: 71-80
- Section: CLINICAL CASE REPORTS
- URL: https://journals.rcsi.science/0042-4609/article/view/126203
- DOI: https://doi.org/10.25208/vdv1369
- ID: 126203
Cite item
Full Text
Abstract
The article presents a description of a clinical case of necrobiosis lipoidica complicated by ulcera-tion in a 55-year-old woman and a brief review of the literature on the topic of modern ideas about necrobiosis lipoidica. The disease manifested itself in 2005 after traumatization of the upper third of both shins as a result of a fall. The patient did visit a dermatologist office for medical help, there was a slow progression of the disease. In 2017, as a result of visiting a dermatologist office at her place of residence, she was diagnosed with necrobiosis lipoidica. The ongoing therapy with vasodi-lators and topical steroids did not lead to significant improvement. In 2021, against the background of vaccination against COVID-19 (22.07.20201 and 12.08.2021 Gam-COVID-Vac — Sputnik V) the patient notes a sharp deterioration of the process after the injection of the second component of the vaccine there were an increased in the area of lesion, ulceration. No data for diabetes mellitus were obtained during the examination. There is a history of a multi-nodular non-toxic goiter, for which a complete resection of the left lobe of the thyroid gland was performed in 1995 and a partial resection of the right lobe of the thyroid gland in 2003. The patient has been receiving L-Thyroxine replacement therapy since 2003. A biopsy of the affected skin was per-formed. The final diagnosis: necrobiosis lipoidica erythematous-ulcerative variant was established according to the pathoanatom-ic examination of the biopsy and atypical clinical picture. As a result of the therapy, the patient was discharged from the clinic with improvement.
Keywords
Full Text
##article.viewOnOriginalSite##About the authors
Daniil I. Cheboksarov
Pavlov First Saint Petersburg State Medical University
Author for correspondence.
Email: tcheboksarov.d@yandex.ru
ORCID iD: 0000-0002-7356-7994
Student
Russian Federation, Saint PetersburgKristina J. Molodykh
Pavlov First Saint Petersburg State Medical University
Email: molodyhkristina@mail.ru
ORCID iD: 0000-0001-5479-5652
SPIN-code: 9472-9640
Assistant Professor
Russian Federation, Saint PetersburgKonstantin N. Monakhov
Pavlov First Saint Petersburg State Medical University
Email: knmonakhov@mail.ru
ORCID iD: 0000-0002-8211-1665
SPIN-code: 1837-2098
MD, Dr. Sci. (Med.), Professor
Russian Federation, Saint PetersburgEvgeny V. Sokolovskiy
Pavlov First Saint Petersburg State Medical University
Email: s40@mail.ru
ORCID iD: 0000-0001-7610-6061
SPIN-code: 6807-7137
MD, Dr. Sci. (Med.), Professor
Russian Federation, Saint PetersburgReferences
- Смирнова Л.М., Семенчак Ю.А., Панченко Л.А. Липоидный некробиоз: обзорная статья. Российский журнал кожных и венерических болезней. 2018;21(1):40–44 [Smirnova LM, Semenchak JuA, Panchenko LA. Lipoid necrobiosis: a review. Rossijskij zhurnal kozhnyh i venericheskih boleznej. 2018;21(1):40–44. (In Russ.)] doi: 10.18821/1560-9588-2018-21-1-40-44
- Платонова А.Н., Бакулев А.Л., Слесаренко Н.А., Моррисон А.В., Шабогина А.А., Давыдова А.В. Липоидный некробиоз (болезнь Оппенгейма — Урбаха). Вестник дерматологии и венерологии. 2012;88(6):70–73 [Platonova AN, Bakulev AL, Slesarenko NA, Morrison AV, Shabogina AA, Davydova AV. Necrobiosis lipoidica (Oppenheim — Urbach disease). Vestnik dermatologii i venerologii. 2012;88(6):70–73. (In Russ.)] doi: 10.25208/vdv758
- Горбунцов В.В., Романенко К.В., Колесникова И.А., Дюдюн А.Д. Клинический случай липоидного некробиоза. Дерматовенерология. Косметология. Сексопатология. 2017;(1-4):216–221 [Gorbuncov VV, Romanenko KV, Kolesnikova IA, Djudjun AD. A clinical case of the necrobiosis lipoidica. Dermatovenerologija. Kosmetologija. Seksopatologija. 2017;(1–4):216–221. (In Russ.)]
- Oppenheim M. Eigentümlich disseminierte Degeneration des Bindegewebes der Haut beieinem Diabetiker. Z Hautkr. 1929; 32:179.
- Urbach E. Eine neue diabetische Stoffwechsel dermatose: Nekrobiosis lipoidica diabeticorum. Arch Dermatol Syphilol. 1932;166:273.
- Goldsmith WN. Necrobiosis Lipoidica. Proc R Soc Med 1935;28(4):363–364.
- Miescher G, Leder M. Granulomatosis disciformis chronica et progressive. Dermatologica. 1948;97(1–3):25–34.
- Rollins TG, Winkelmann RK. Necrobiosis lipoidica granulomatosis. Necrobiosis lipoidica diabeticorum in the nondiabetic. Arch Dermatol. 1960;82:537–543. doi: 10.1001/archderm.1960.01580040055010
- Lepe K, Riley CA, Salazar FJ. Necrobiosis Lipoidica. Treasure Island: StatPearls Publishing; 2022. https://www.statpearls.com/ArticleLibrary/viewarticle/25619 (Accessed: 20 November 2022).
- Berman HS, Shabihkhani M, Hogeling M. Pediatric necrobiosis lipoidica: case report and review of the literature. Dermatol Online J. 2021;27(7). doi: 10.5070/D327754363
- Думченко В.В., Шашкова А.А., Тарасенко Э.М. Случай липоидного некробиоза у ребенка. Вестник дерматологии и венерологии. 2017;93(1):51–54 [Dumchenko VV, Shashkova AA, Tarasenko JeM. The case of necrobiosis lipoidica in a child. Vestnik dermatologii i venerologii. 2017;93(1):51–54 (In Russ.)] doi: 10.25208/0042-4609-2017-93-1-51-54
- Sibbald C, Reid S, Alavi A. Necrobiosis Lipoidica. Dermatol Clin. 2015;33(3):343–360. doi: 10.1016/j.det.2015.03.003
- Absil G, Collins P, El Hayderi L, Nikkels AF. Necrobiosis Lipoidica following Breast Reduction. Plast Reconstr Surg Glob Open. 2021;9(9):e3788. doi: 10.1097/GOX.0000000000003788
- Miller RA. Koebner phenomenon in a diabetic with necrobiosis lipoidica diabeticorum. Int J Dermatol. 1990;29(1):52–53. doi: 10.1111/j.1365-4362.1990.tb03757.x
- Ghate JV, Williford PM, Sane DC, Hitchcock MG. Necrobiosis lipoidica associated with Köbner's phenomenon in a patient with diabetes. Cutis. 2001;67(2):158–160.
- Grillo E, Rodriguez-Muñoz D, González-Garcia A, Jaén P. Necrobiosis lipoidica. Aust Fam Physician. 2014;43(3):129–130.
- Erfurt-Berge C, Dissemond J, Schwede K, Seitz AT, Al Ghazal P, Wollina U, et al. Updated results of 100 patients on clinical features and therapeutic options in necrobiosis lipoidica in a retrospective multicentre study. Eur J Dermatol. 2015;25(6):595–601. doi: 10.1684/ejd.2015.2636
- Feily A, Mehraban S. Treatment Modalities of Necrobiosis Lipoidica: A Concise Systematic Review. Dermatol Reports. 2015;7(2):5749. doi: 10.4081/dr.2015.5749
- Remes K, Rönnemaa T. Healing of chronic leg ulcers in diabetic necrobiosis lipoidica with local granulocyte-macrophage colony stimulating factor treatment. J Diabetes Complications. 1999;13(2):115–118. doi: 10.1016/s1056-8727(98)00025-7
- Peckruhn M, Tittelbach J, Elsner P. Update: Treatment of necrobiosis lipoidica. J Dtsch Dermatol Ges. 2017;15(2):151–157. doi: 10.1111/ddg.13186
- Burns E, Ukoha U, Chan A. Necrobiosis lipoidica with rapid response to doxycycline. Pediatr Dermatol. 2020;37(5):981–982. doi: 10.1111/pde.14295
- Erfurt-Berge C, Sticherling M. Successful treatment of ulcerative necrobiosis lipoidica with janus kinase inhibitor. J Eur Acad Dermatol Venereol. 2020;34(7):e331–e333. doi: 10.1111/jdv.16297
- Barbet-Massin MA, Rigalleau V, Blanco P, Mohammedi K, Poupon P, Belin E, et al. Remission of necrobiosis lipoidica diabeticorum with a JAK1/2 inhibitor: A case report. Diabetes Metab. 2021;47(4):101143. doi: 10.1016/j.diabet.2020.01.001
- Rajabi-Estarabadi A, Aickara DJ, Hirsch M, Williams NM, Maranda EL, Van Badiavas E. Laser and light therapies for the treatment of necrobiosis lipoidica. Lasers Med Sci. 2021;36(3):497–506. doi: 10.1007/s10103-020-03147-3
Supplementary files
