New aspects of the pathogenesis of psoriasis

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Abstract

Psoriasis is a chronic multi-factorial immune-mediated inflammatory disease of skin and joints. The variety of clinical forms of dermatosis is consistent with various pathogenetic features of the disease progress which have been significantly supplemented and reviewed recently. Knowledge of these mechanisms will improve and personalize the prescribed therapy.

This study places the emphasis on modern ideas about the formation of T cell memory, the role of melanocytes and innate lymphoid cells. Development mechanisms of guttate and paradoxical psoriasis with important distinguishing characteristics are described separately.

Today, knowledge of the molecular basis of the disease progression has led to the creation and introduction of a number of highly effective targeted drugs into clinical practice. Further developments related to the inhibition of resident memory cells, innate lymphoid cells, as well as the study of guttate psoriasis perpetuation and the occurrence of paradoxical psoriasis will significantly increase the effectiveness of the therapy.

About the authors

Alexander S. Zhukov

S.M. Kirov Military Medical Academy

Author for correspondence.
Email: doctor-vma@mail.ru
ORCID iD: 0000-0002-4915-9157
SPIN-code: 4570-3470

MD, Cand. Sci. (Med.)

Russian Federation, 6, Akademika Lebedeva str., Saint Petersburg, 194044

Alexander V. Patrushev

S.M. Kirov Military Medical Academy

Email: alexpat2@yandex.ru
ORCID iD: 0000-0002-6989-9363
SPIN-code: 1367-5580

MD, Dr. Sci. (Med.)

Russian Federation, 6, Akademika Lebedeva str., Saint Petersburg, 194044

Vladislav R. Khairutdinov

S.M. Kirov Military Medical Academy

Email: haric@mail.ru
ORCID iD: 0000-0002-0387-5481
SPIN-code: 4417-9117

MD, Dr. (Sci.) Med., assistant professor

Russian Federation, 6, Akademika Lebedeva str., Saint Petersburg, 194044

Alexey V. Samtsov

S.M. Kirov Military Medical Academy

Email: avsamtsov@mail.ru
ORCID iD: 0000-0002-9458-0872
SPIN-code: 2287-5062

MD, Dr. (Sci.) Med, Professor

Russian Federation, 6, Akademika Lebedeva str., Saint Petersburg, 194044

Evgeniy V. Kryukov

S.M. Kirov Military Medical Academy

Email: evgeniy.md@mail.ru
ORCID iD: 0000-0002-8396-1936
SPIN-code: 3900-3441

MD, Dr. (Sci.) Med, Professor, Academician of the Russian Academy of Sciences

Russian Federation, 6, Akademika Lebedeva str., Saint Petersburg, 194044

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3. Fig. 2. Immunohistochemical study (dual detection system): neutral red staining — marker Ki-67, Bismarck brown staining — marker MelanA); magn: ×200, 696 × 507 μm

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4. Fig. 3. Immunohistochemical study (dual detection system). Sporadic proliferating melanocyte (MelanA+-Ki67+-cell) in the epidermis of psoriasis patients (marked by an arrow); magn. ×400, 348 × 253 μm

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5. Fig. 4. Immunohistochemical study (dual detection system). The contacts of MelanA+ cells (Bismarck brown staining) and CD8+ cells (neutral red staining) in the epidermis (marked by arrows); magn. ×400, 348 × 253 μm

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Copyright (c) 2022 Zhukov A.S., Patrushev A.V., Khairutdinov V.R., Samtsov A.V., Kryukov E.V.

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