Lechenie «dermatita otmeny» posleprimeneniya topicheskikh glyukokortikosteroidovs ispol'zovaniem aktivirovannogo tsinkapiritiona
- Authors: Perlamutrov y.N1, Ol'khovskaya KB1, PERLAMUTROV Y.N1, OLKHOVSKAYA KB1
-
Affiliations:
- МГМСУ
- Issue: Vol 87, No 6 (2011)
- Pages: 63-67
- Section: Articles
- URL: https://journals.rcsi.science/0042-4609/article/view/117478
- DOI: https://doi.org/10.25208/vdv1091
- ID: 117478
Cite item
Full Text
Abstract
The authors present the results of a study of efficiency of Skin-Cap in treatment of withdrawal dermatitis after application
of topical glucocorticosteroids.
The study involved 46 patients who had topical corticosteroids applied on their face skin in the anamnesis, who were
divided into two groups depending on the therapy. The efficiency of treatment was assessed based on the dynamics of the
Dermatological Index of Symptom Scale (DISS).
A comparative assessment of the efficiency of treatment with the use of the Skin-Cup cream and non-specific antiinflammatory
drugs showed the highest efficiency of application of activated zinc pyrithione, which was became apparent in
reliably more intensive reduction of the DISS and certain subjective and objective symptoms of the inflammatory reaction.
Good results of the study substantiate the expediency of administration of Skin-Cap in treatment of patients with
symptoms of withdrawal dermatitis as this drug facilitates the course of the disease and results in faster elimination of
the inflammation. Application of the cream containing activated zinc pyrithione makes it possible to avoid administration
of system drugs.
of topical glucocorticosteroids.
The study involved 46 patients who had topical corticosteroids applied on their face skin in the anamnesis, who were
divided into two groups depending on the therapy. The efficiency of treatment was assessed based on the dynamics of the
Dermatological Index of Symptom Scale (DISS).
A comparative assessment of the efficiency of treatment with the use of the Skin-Cup cream and non-specific antiinflammatory
drugs showed the highest efficiency of application of activated zinc pyrithione, which was became apparent in
reliably more intensive reduction of the DISS and certain subjective and objective symptoms of the inflammatory reaction.
Good results of the study substantiate the expediency of administration of Skin-Cap in treatment of patients with
symptoms of withdrawal dermatitis as this drug facilitates the course of the disease and results in faster elimination of
the inflammation. Application of the cream containing activated zinc pyrithione makes it possible to avoid administration
of system drugs.
About the authors
yu N Perlamutrov
МГМСУд.м.н., профессор, зав. кафедрой кожных и венерическихболезней; МГМСУ
K B Ol'khovskaya
МГМСУк.м.н., доцент кафедры кожных и венерических болезней; МГМСУ
YU N PERLAMUTROV
K B OLKHOVSKAYA
References
- Игнатьев Д.В., Кочергин Н.Ф. Местные кортикостероиды в практике врача-дерматолога. Особенности гидрокортизона бутирата (локоида). Приложение Consillium medicum, Дерматология. 2007; 1: 51-58.
- Roumestan C., Henriquet C., Bousquet J. et al. Fluticasone propionate and mometasone furoate have equivalent transcriptional potencies. Clinical Exp Allergy 2003; 33: 895-901.
- Green С., Colquitt J.L., Kirby J. et al. Clinical and cost-effectiveness of once-daily versus more frequent use of same potency topical corticosteroids for atopic eczema: a systematic review and economic evaluation. Health Technological Assessment 2004; 8: 47.
- Филимонкова Н.Н., Чуверова К.А., Ян И.А. Наружная терапия больных псориазом. Клин. дерматол. и венерол. 2009; 2: 51-53.
- Кочергин Н.Г., Белоусова Т.А. К вопросу о местной кортикостероидной терапии. Росс. журн. кож. и вен. бол. 2001; 2: 28-31.
- Кутасевич Я.Ф. Современные подходы к применению топических глюкокортикостероидов. Дерматология и венерология. 2000; 1: 95-99.
- Короткий Н.Г., Тихомиров А.А., Гамаюнов Б.Н. Локоид в терапии хронических воспалительных заболеваний кожи у детей. Педиатрия. 2006; 3: 56-60.
- Мокроносова М.А., Глушакова А.М., Голышева Е.В., Обоснование отсутствия синдрома отмены препарата Скин-кап: антимикотическая активность цинка пиритиона. Клин. дерматол. и венерол. 2008; 5: 69-72.
- Балаболкин И.И., Гребенюк В.Н., Капустина Е.Ю. Наружное лечение атопического дерматита у детей. Педиатрия. 2007; 86 (2): 97.
- Ermolayeva Е., Sanders D. Mechanism of pyrithione-induced membrane depolarization in Neurospora crassa. Applied Environmental Microbiology 1995; 61(9): 3385-3390.
- Dinning A.J., Al-Adham I.S., Eastwood I.M. et al. Pyrithione biocides as inhibitors of bacterial ATP synthesis. Journal Applied Microbiology 1998; 85(1): 141-146.
- Mann J.J., Fraker P.J. Zinc pyrithione induces apoptosis and increases expression of Bim. Apoptosis 2005; 10(2): 369-379.
- Казначеев К.С., Казначеева Л.Ф., Молокова А.В. Апоптоз клеток-мигрантов кожи у детей с атопическим дерматитом на фоне применения крема Скин-кап. Аллергология. 2006; 3: 7-11.
- Волкова Е.Н. Атопический дерматит. Лечащий врач. 2006; 9: 22-29.
- Феденко Е.С. Атопический дерматит: обоснование поэтапного подхода к терапии. Consilium Medicum. 2001; 3(4): 176-184.
- Кочергин Н.Г., Новоселов B.C., Белоусова Т.А. Индекс шкалы симптомов в дерматологической практике. Региональная конференция «Актуальные вопросы дерматологии, микологии, заболеваний, передаваемых половым путем». Иркутск, 1998: 21-22.
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