Association of polymorphism of IL12B gene and predisposition to psoriasis among the populationof the Northwestern region of Russia
- Authors: Khayrutdinov VR1, Mikhaylichenko AF1, Piskunova AA2, Samtsov AV1, Ivanov AM1, Imyanitov EN3, KHAIRUTDINOV VR3, MIKHAILICHENKO AF3, PISKUNOVA AA3, SAMTSOV AV3, IVANOV AM3, IMYANITOV Y.N3
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Affiliations:
- Военно-медицинская академия им. С.М. Кирова
- Санкт-Петербургская медицинская академия последипломного образования
- НИИ онкологииим. Н.Н. Петрова
- Issue: Vol 87, No 6 (2011)
- Pages: 25-28
- Section: Articles
- URL: https://journals.rcsi.science/0042-4609/article/view/117468
- DOI: https://doi.org/10.25208/vdv1079
- ID: 117468
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Full Text
Abstract
part in the pathogenesis of psoriasis. The IL12B gene has polymorphism rs12188300, which can be associated with the
risk of psoriasis development. The goal of the study was to assess the distribution of alleles of polymorphism rs12188300
in psoriatic patients in the Northwestern region of Russia. Genotyping was carried out using the real-time allele-specific
polymerase chain reaction. An increased occurrence of a rare allele T in psoriatic patients as compared to healthy people
was observed (OR = 1.96, р = 0.0007). The occurrence of the rare allele T in patients with psoriatic arthritis was higher
than in the control group (OR = 3.49, р = 0.005). These results suggest that rs12188300 polymorphism of the IL12B gene
is a new genetic marker of psoriasis and psoriatic arthritis.
About the authors
V R Khayrutdinov
Военно-медицинская академия им. С.М. Кировастарший ординатор кафедры кожных и венерических болезней; Военно-медицинская академия им. С.М. Кирова
A F Mikhaylichenko
Военно-медицинская академия им. С.М. Кировастарший лаборант НИЛ микробиологической безопасностии профилактики особо опасных инфекций НИО нанобиотехнологий; Военно-медицинская академия им. С.М. Кирова
A A Piskunova
Санкт-Петербургская медицинская академия последипломного образованияасп. кафедры дерматовенерологии и косметологии; Санкт-Петербургская медицинская академия последипломного образования
A V Samtsov
Военно-медицинская академия им. С.М. Кированачальник кафедры кожных и венерических болезней; Военно-медицинская академия им. С.М. Кирова
A M Ivanov
Военно-медицинская академия им. С.М. Кированачальник научно-исследовательского отдела нанобиотехнологий; Военно-медицинская академия им. С.М. Кирова
E N Imyanitov
НИИ онкологииим. Н.Н. Петроваруководитель отдела биологии опухолевого роста; НИИ онкологииим. Н.Н. Петрова
V R KHAIRUTDINOV
A F MIKHAILICHENKO
A A PISKUNOVA
A V SAMTSOV
A M IVANOV
YE N IMYANITOV
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