Systemic therapy of acne in teenagers


Cite item

Full Text

Abstract

The goal was to determine clinical and anamnestic features of acne patients aged up to 18 years needing systemic isotretinoin treatment, and to assess the treatment dynamics. Materials and methods. The authors conducted a study of 27 patients with moderate to severe acne (with the mean age of 16.2 ± 1.2 years) receiving isotretinoin in the form of LIDOSE (Acnecutan) in the dose of 0.33 ± 0.06 mg/kg. Results. A steady improvement of the skin condition was observed when the dose of isotretinoin in the form of LIDOSE of 60.3 ± 2.8 mg/kg was used. Clinical recovery was observed in all of the patients (the cumulative dose amounted to 100 mg/kg). Teenagers demonstrated good tolerance to the drug and had no systemic adverse effects.

About the authors

I G Sergeyeva

Novosibirsk State University

Email: mojmaj@mail.ru
д.м.н, профессор кафедры фундаментальной медицины Pirogova street 2, 630090, Novosibirsk, Russia

Yu M Krinitsyna

Novosibirsk State University; Research Institute of Regional Pathology and Pathomorphology, Siberian Department of the Russian Academy of Medical Sciences

д.м.н., профессор, заведующая лабораторией Pirogova street 2, 630090, Novosibirsk, Russia; Akad. Timakova street 2, 630117, Novosibirsk, Russia

N G Makarova

Novosibirsk State University

ординатор медицинского факультета Pirogova street 2, 630090, Novosibirsk, Russia

A A Dyagileva

Novosibirsk State University

студентка медицинского факультета Pirogova street 2, 630090, Novosibirsk, Russia

References

  1. Goldberg J.L., Dabade T.S., Davis S.A. et al. Changing age of acne vulgaris visits: another sign of earlier puberty? Pediatr Dermatol 2011; 28 (6): 645—648.
  2. Jankovic S., Vukicevic J., Djordjevic S., Jankovic J., Marinkovic J. Quality of life among schoolchildren with acne: results of a cross-sectional study. Indian J Dermatol Venereol Leprol 2012; 78 (4): 454—458.
  3. Law M.P., Chuh A.A., Lee A., Molinari N. Acne prevalence and beyond: acne disability and its predictive factors among Chinese late adolescents in Hong Kong. Clin Exp Dermatol 2010; 35 (1): 16—21.
  4. Halvorsen J.A., Stern R.S., Dalgard F. et al. Suicidal ideation, mental health problems, and social impairment are increased in adolescents with acne: a population-based study. J Invest Dermatol 2011; 131 (2): 363—370.
  5. Corey K.C., Cheng C.E., Irwin B., Kimball A.B. Self-reported help-seeking behaviors and treatment choices of adolescents regarding acne. Pediatr Dermatol 2013; 30 (1): 36—41.
  6. Мурашкин Н.Н., Иванов А.М., Заславский Д.В., Камилова Т.А. Вопросы эффективности и безопасности применения системных ретиноидов в терапии акне у подростков. Вестн дерматол и венерол 2010; (5): 12—116.
  7. Nast A., Dreno B., Bettoli V. European evidens-based (S3) guidelines for the treatment of acne. JEADV 2012; 26, suppl. 1.
  8. Львов А.Н. Роаккутан в терапии угревой болезни: новая схема низких доз. Вестн дерматол и венерол 2009; (2): 88—93.
  9. Rademaker M. Adverse effects of isotretinoin: A retrospective review of 1743 patients started on isotretinoin. Australas J Dermatol 2010; 51 (4): 248—253.
  10. Agarwal U.S., Besarwal R.K., Bhola K. Oral isotretinoin in different dose regimens for acne vulgaris: a randomized comparative trial. Indian J Dermatol Venereol Leprol 2011; 77 (6): 688—694.
  11. Uslu G., Sendur N., Uslu M. et al. Acne: prevalence, perceptions and effects on psychological health among adolescents in Aydin, Turkey. J Eur Acad Dermatol Venereol 2008; 22 (4): 462—469.

Supplementary files

Supplementary Files
Action
1. JATS XML
Download

Copyright (c) 2013 Sergeyeva I.G., Krinitsyna Y.M., Makarova N.G., Dyagileva A.A.

Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 International License.

Согласие на обработку персональных данных

 

Используя сайт https://journals.rcsi.science, я (далее – «Пользователь» или «Субъект персональных данных») даю согласие на обработку персональных данных на этом сайте (текст Согласия) и на обработку персональных данных с помощью сервиса «Яндекс.Метрика» (текст Согласия).